Concept

Glycogen phosphorylase

Related publications (53)

In vivo 13C NMR studies of compartmentalized cerebral carbohydrate metabolism

Localized 13C nuclear magnetic resonance (NMR) spectroscopy provides a unique window for studying cerebral carbohydrate metabolism through, e.g. the completely non-invasive measurement of cerebral glucose and glycogen metabolism. In addition, label incorpo ...

Elsevier2002

A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression

Pierre Magistretti, Igor Allaman, Sylvain Eric Lengacher, Luc Pellerin

Adenosine has been proposed as a key factor regulating the metabolic balance between energy supply and demand in the central nervous system. Because astrocytes represent an important cellular element in the control of brain energy metabolism, we investigat ...

2002

Quantitative analysis of the impact of HXK2 and REG1 deletion in Saccharomyces cerevisiae on invertase expression and respiration

Urs von Stockar, Ian William Marison, Christoph Herwig

In Saccharomyces cerevisiae, the genes HXK2 and REG1 are believed to play a central role in carbon catabolite repression, acting on multiple pathways in the central metab. The present study aimed at quantifying the effect of deletion of genes HXK2 or REG1, ...

2002

Protein targeting to glycogen mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes

Pierre Magistretti, Igor Allaman, Luc Pellerin

Brain glycogen levels are dynamically regulated by certain neurotransmitters, including noradrenaline (NA) and vasoactive intestinal peptide (VIP). In particular, glycogen synthesis involves activation by NA and VIP of the transcription factors C/EBPbeta a ...

Wiley-Blackwell2000

Single-shot, three-dimensional 'non-echo' localization method for in vivo NMR spectroscopy

Rolf Gruetter

Metabolite signals with short T1 or T2 are difficult to localize with full sensitivity. This limitation was overcome with the development and implementation of a single-shot, complete three-dimensional 'non-echo' localization method with reduced sensitivit ...

2000

Deep hypothermia and rewarming alters glutamate levels and glycogen content in cultured astrocytes

Pierre Magistretti, Luc Pellerin

BACKGROUND: Deep hypothermia has been associated with an increased incidence of postoperative neurologic dysfunction after cardiac surgery in children. Recent studies suggest an excitotoxic mechanism involving overstimulation of glutamate receptors. Extrac ...

1999

Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse cortical astrocytes: involvement in cAMP-regulated glycogen metabolism

Pierre Magistretti, Jean-René Cardinaux

We have described previously a transcription-dependent induction of glycogen resynthesis by the vasoactive intestinal peptide (VIP) or noradrenaline (NA) in astrocytes, which is mediated by cAMP. Because it has been postulated that the cAMP-mediated regula ...

1996

Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes

Pierre Magistretti, Luc Pellerin

Adenosine triphosphate (ATP) promotes glycogenolysis in primary cultures of mouse cerebral cortical astrocytes with an EC50 of 1.5 microM. A pharmacological analysis indicates an involvement of purinergic P2Y receptors in this action of ATP. Application of ...

1995

Validation of 13C NMR measurements of liver glycogen in vivo

Rolf Gruetter

The natural abundance 13C NMR intensity of the glycogen C1 resonance was measured in the surgically exposed liver of rabbits in vivo (n = 17) by integration from 98 to 104 ppm and compared double blindedly to the subsequent biochemical measurement. Coil lo ...

1994

Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: blockade by protein synthesis inhibition

Pierre Magistretti

Vasoactive intestinal peptide (VIP) and noradrenaline (NA) have been previously shown to promote glycogenolysis in mouse cerebral cortex (Magistretti, 1990). This action, which is fully expressed within a few minutes, is exerted on astrocytes (Sorg and Mag ...

1992

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