Concept

Clomipramine

Related publications (13)

Elucidating and modulating regulatory pathways so as to reprogram the immunosuppressive tumor microenvironment for therapeutic benefit

Glioblastoma (GBM) is the most frequent and highly malignant form of brain cancer. New therapeutic regimens are urgently needed as GBM patients present with a minimal response to currently-approved therapies. The goal of this project is to identify new the ...

EPFL2023

Combinatorial targeting of angiogenesis with inducers of autophagy in the treatment of glioblastoma multiforme

Julie Laetitia Scotton

Malignant gliomas represent 80% of tumors developing in the central nervous system, with 50% being glioblastomas (GBM), the most aggressive form of the disease. The benefit from current therapies is very limited, the overall 5-year survival rate of patient ...

EPFL2018

Cortical Dynamics in Presence of Assemblies of Densely Connected Weight-Hub Neurons

Wulfram Gerstner, Moritz Deger, Hesam Setareh

Experimental measurements of pairwise connection probability of pyramidal neurons together with the distribution of synaptic weights have been used to construct randomly connected model networks. However, several experimental studies suggest that both wiri ...

Frontiers Research Foundation2017

Immunogold characteristics of VGLUT3-positive GABAergic nerve terminals suggest corelease of glutamate

Mats Julius Stensrud

There is compelling evidence that glutamate can act as a cotransmitter in the mammalian brain. Interestingly, the third vesicular glutamate transporter (VGLUT3) is primarily found in neurons that were anticipated to be nonglutamatergic. Whereas the functio ...

2015

Estimation and Modeling of QT-Interval Adaptation to Heart Rate Changes

Jean-Marc Vesin

This paper introduces a new method for QT-interval estimation. It consists in a batch processing mode of the improved Woody's method. Performance of this methodology is evaluated using synthetic data. In parallel, a new model of QT-interval dynamics behavi ...

2012

Defining new criteria for selection of cell-based intestinal models using publicly available databases

Michel Aguet, Mauro Delorenzi, Pascale Anderle Pedone, Thierry Sengstag

Background: The criteria for choosing relevant cell lines among a vast panel of available intestinal-derived lines exhibiting a wide range of functional properties are still ill-defined. The objective of this study was, therefore, to establish objective cr ...

BioMed Central2012

Surface modifications based on the cyanobacterial siderophore anachelin: from structure to functional biomaterials design

Karl Gademann, Jean-Yves Wach, Joanna Kobylinska, Tom Woods

This review describes the design, synthesis and evaluation of novel catechol based anchors for surface modification. The anachelin chromophore, the catecholate fragment of the siderophore anachelin from the cyanobacterium Anabaena cylindrica, allows for th ...

Springer Netherlands2009

Successive refinement for hypothesis testing and lossless one-helper problem

Jun Chen

We investigate two closely related successive refinement (SR) coding problems: 1) In the hypothesis testing (HT) problem, bivariate hypothesis H-o : P-XY against H-1 : P-X P-Y, i.e., test against independence is considered. One remote sensor collects data ...

2008

In vitro and in vivo ligand binding to the 5HT3 serotonin receptor characterised by time-resolved fluorescence spectroscopy

Horst Vogel, Rudolf Hovius, Horst Pick

The binding of the fluorescein-labeled antagonist GR-flu ([1,2,3,9-tetrahydro-3-[(5-methyl-1H-imidazol-4-yl)methyl]-9-(3-amino- (N-fluoresceinthiocarbamoyl)propyl)-4H-carbazol-4-one]) to a purified, detergent-solubilized ligand-gated ion channel, the type- ...

2001

Characterization of a mouse serotonin 5-HT3 receptor purified from mammalian cells

Horst Vogel, Rudolf Hovius, Alain Bernard

A serotonin 5-HT3 receptor was functionally expressed to high levels and on a large scale in mammalian cells with the Semliki Forest virus system. Conditions were optimized to maximize detergent solubilization of the receptor, while preserving ligand bindi ...

1998

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