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Current challenges in understanding the role of enhancers in disease

Bart Deplancke

Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing eviden ...

NATURE PORTFOLIO2022

A comprehensive review of digital twin - part 1: modeling and twinning enabling technologies

Olga Fink, Chao Hu, Sayan Ghosh

As an emerging technology in the era of Industry 4.0, digital twin is gaining unprecedented attention because of its promise to further optimize process design, quality control, health monitoring, decision and policy making, and more, by comprehensively mo ...

SPRINGER2022

Assortment optimization using an attraction model in an omnichannel environment

Ralf Seifert, Andrey Vasilyev, Sebastian Maier

Making assortment decisions is becoming an increasingly difficult task for many retailers worldwide as they implement omnichannel initiatives. Discrete choice modeling lies at the core of this challenge, yet existing models do not sufficiently account for ...

2023

The microbiome of cryospheric ecosystems

Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Tyler Joe Kohler, Stylianos Fodelianakis

The cryosphere includes those parts of Earth where water or soil is frozen, such as snow, ice, glaciers and permafrost soils. Here, the authors present a global inventory of cryospheric microbial communities and their genetic repertoires. ...

Nature Portfolio2022

On the development of multi-physics tools for nuclear reactor analysis based on OpenFOAM (R): state of the art, lessons learned and perspectives

Carlo Fiorina

In the last two decades, the use of OpenFOAM as a multi-physics library for nuclear applications has grown from a sporadic use for exploratory studies to a widespread application for the analysis of innovative reactor concepts and highly complex problems. ...

ELSEVIER SCIENCE SA2022

Quality criteria for multi-domain studies in the indoor environment: Critical review towards research guidelines and recommendations

Dolaana Khovalyg, Verena Marie Barthelmes, Matteo Favero, Giorgia Chinazzo, Mandana Sarey Khanie

The perception, physiology, behavior, and performance of building occupants are influenced by multi-domain exposures: the simultaneous presence of multiple environmental stimuli, i.e., visual, thermal, acoustic, and air quality. Despite being extensive, th ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Politics of Urban Planning : The Making and Unmaking of the Mumbai Development Plan 2014-2034

Luca Giovanni Pattaroni

This book offers an interdisciplinary and dynamic account of the politicization of urban planning in Mumbai, India. It presents a unique perspective on the tensions and conflicts pervading the development and regulation of contemporary cities in the wider ...

Springer2022

Re-creating Memories of Gulou: Three Temporalities and Emotions

Florence Graezer Bideau

In 2012, a project proposed by local authorities aimed to revitalise, after a century of interruption, the use of Beijing’s Bell and Drum Towers and the social traditions associated with them. As a result, more than 100 households living in 66 traditional ...

Routledge2021

A generalized theory of separable effects in competing event settings

Mats Julius Stensrud

In competing event settings, a counterfactual contrast of cause-specific cumulative incidences quantifies the total causal effect of a treatment on the event of interest. However, effects of treatment on the competing event may indirectly contribute to thi ...

2021

Testing two competing hypotheses for Eurasian jays' caching for the future

Johanni Michael Brea

Previous research reported that corvids preferentially cache food in a location where no food will be available or cache more of a specific food in a location where this food will not be available. Here, we consider possible explanations for these prospect ...

NATURE RESEARCH2021

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