Concept

Homology directed repair

Related publications (32)

Mus81-Mms4 Functions as a Single Heterodimer To Cleave Nicked Intermediates in Recombinational DNA Repair

The formation of crossovers is a fundamental genetic process. The XPF-family endonuclease Mus81-Mms4 (Eme1) contributes significantly to crossing over in eukaryotes. A key question is whether Mus81-Mms4 can process Holliday junctions that contain four unin ...

American Society for Microbiology2012

Statistical analysis of the current-sharing temperature evolution in Nb3Sn cable-in-conduit-conductors for ITER

Pierluigi Bruzzone, Davide Uglietti, Boris Stepanov, Rainer Wesche

During the test of ITER conductors at nominal conditions, a degradation of the current sharing temperature has been observed after electromagnetic cyclic loading. Rather than focusing on the microscopic phenomena at the origin of the degradation, the degra ...

IEEE-Inst Electrical Electronics Engineers Inc2012

Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Henning Paul-Julius Stahlberg, Jie Liu

Homologous recombination is a high-fidelity DNA repair pathway. Besides a critical role in accurate chromosome segregation during meiosis, recombination functions in DNA repair and in the recovery of stalled or broken replication forks to ensure genomic st ...

Springer Nature2011

Stem cell-based cardiovascular tissue engineering

Thomas Krähenbühl

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009

The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

BACKGROUND: Microsporidia, parasitic fungi-related eukaryotes infecting many cell types in a wide range of animals (including humans), represent a serious health threat in immunocompromised patients. The 2.9 Mb genome of the microsporidium Encephalitozoon ...

BioMed Central2007

Double hexameric ring assembly of the type III protein translocase ATPase HrcN

Henning Paul-Julius Stahlberg, Andreas Engel

The specialized type III secretion (T3S) apparatus of pathogenic and symbiotic Gram-negative bacteria comprises a complex transmembrane organelle and an ATPase homologous to the F-1-ATPase beta subunit. The T3S ATPase HrcN of Pseudomonas syringae associate ...

Wiley-Blackwell2006

A Probabilistic Measure of Modality Reliability in Speaker Verification

Jonas Richiardi, Andrzej Drygajlo, Plamen Prodanov

In this paper, a probabilistic measure for reliability of speaker verification under noisy acoustic conditions is proposed. A Bayesian network is used to estimate a probability for verification errors, given the GMM-based speaker verification system output ...

IEEE2005

A Probabilistic Measure of Modality Reliability in Speaker Verification

2005

Cisplatin binding to DNA oligomers from hybrid Car-Parrinello/molecular dynamics simulations

Ursula Röthlisberger, Paolo Carloni

Cisplatin is widely used in clinic treatment against a variety of cancer diseases. It binds to two adjacent guanine residues and induces a bend in the DNA double helix. It is believed that cell death is induced upon binding of proteins, which recognize pla ...

2004

Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres

Joachim Lingner

Yeast telomeres consist of approximately 300 nt of degenerate repeats with the consensus sequence G(2-3)(TG)(1-6). We developed a method for the amplification of a genetically marked telomere by PCR, allowing precise length and sequence determination of th ...

2000

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