Concept

Three-domain system

Related publications (43)

Pde-Constrained Optimization For Nuclear Mechanics

We propose an image based PDE-constrained optimisation framework to compute the dynamical quantities of a cell nucleus undergoing deformation. It allows retrieving the displacement, strain and stress at each pixel of the nuclear domain, as well as the trac ...

IEEE2022

NAD(+) Precursors: A Questionable Redundancy

Carlos Canto Alvarez

The last decade has seen a strong proliferation of therapeutic strategies for the treatment of metabolic and age-related diseases based on increasing cellular NAD(+) bioavailability. Among them, the dietary supplementation with NAD(+) precursors-classicall ...

MDPI2022

A non-twisting flux tube for local gyrokinetic simulations

Stephan Brunner, Justin Richard Ball

Local gyrokinetic simulations use a field-aligned domain that twists due to the magnetic shear of the background magnetic equilibrium. However, if the magnetic shear is strong and/or the domain is long, the twist can become so extreme that it fails to prop ...

2021

The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity

Didier Trono, Matteo Dal Peraro, Suliana Manley, Jenny Sülzle, Annamaria Kauzlaric, Alice Duperrex

Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases. Currently, whether and how oligomerization impacts their biochemical and biological fun ...

2020

MATHICSE technical Report : A parabolic local problem with exponential decay of the resonance error for numerical homogenization

Doghonay Arjmand, Edoardo Paganoni

This paper aims at an accurate and ecient computation of eective quantities, e.g., the homogenized coecients for approximating the solu- tions to partial dierential equations with oscillatory coecients. Typical multiscale methods are based on a micro-macro ...

MATHICSE2020

On The Behavior Of Clamped Plates Under Large Compression

We determine the asymptotic behavior of eigenvalues of clamped plates under large compression by relating this problem to eigenvalues of the Laplacian with Robin boundary conditions. Using the method of fundamental solutions, we then carry out a numerical ...

2019

Atomic Force Microscopy of Biological Systems: Quantitative Imaging and Nanomotion Detection

Petar Stupar

The core of this thesis is the application of different modalities of atomic force microscopy to study living systems. After a brief introduction, quantitative imaging state of the art is presented and the applications for mammalian, plant, bacterial, and ...

EPFL2018

Mitochondrial activity detected by cantilever based sensor

Giovanni Dietler, Sandor Kasas, Petar Stupar, Wojciech Chomicki

Our team recently demonstrated that cantilever based devices can detect signature of life in a chemistry independent manner. In this technique, the organism of interest is attached onto a classical AFM cantilever. If alive, it induces nanometre scale oscil ...

Copernicus GmbH2017

Chemometric Analysis of Bacterial Peptidoglycan Reveals Atypical Modifications That Empower the Cell Wall against Predatory Enzymes and Fly Innate Immunity

Bruno Lemaitre

Peptidoglycan is a fundamental structure for most bacteria. It contributes to the cell morphology and provides cell wall integrity against environmental insults. While several studies have reported a significant degree of variability in the chemical compos ...

American Chemical Society2016

Chromatin organization, transcription factor dynamics and gene expression in higher eukaryotes with superresolution imaging and single molecule tracking

Aleksandr Benke

Gene expression is dynamic and heterogeneous across all cell types. It serves several fundamental functions such as adaptation for changing environment and developing tissue specific phenotype and functionality during development and in adult organism. Con ...

EPFL2015

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