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Fractal analysis in the quantification of medical imaging associated with multiple sclerosis pathology

Maria-Alexandra Paun

Backgrounds: Multiple sclerosis (MS) is an inveterate phlogistic situation characterized by focal and vaguely diffusive de-myelination and neurodegeneration, in the sphere of central nervous system (CNS). The brain's chronic inflammatory reaction includes ...

IMR PRESS2022

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Traian Popa

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentia ...

ELSEVIER IRELAND LTD2022

The role of the Nimrod proteins in the Drosophila immune system

Bianca Marie Petrignani

The use of tractable model organisms such as Drosophila melanogaster and the powerful genetic tools they offer has contributed significantly to recent advances in comprehension of innate immunity, notably phagocytosis. To date, several phagocytic transmemb ...

EPFL2022

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Claudia Kathe, Jordan Squair, Yi Ding

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

Nature Portfolio2022

Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes

Ece Yildiz

In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study invest ...

WILEY-V C H VERLAG GMBH2022

Developing new tools to study and program cell fate at the single-cell level

Marjan Biocanin

Single-cell transcriptomics (scRNA-seq) started a technological revolution in biology by enabling through the plethora of methods to assess a molecular state of the cell on systems level without the strict necessity of the prior knowledge of the cell state ...

EPFL2021

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila

Bruno Lemaitre, Samuel Rommelaere, Florent François Masson, Elodie Julie Virginie Ramond, Bianca Marie Petrignani

Programmed cell death plays a fundamental role in development and tissue homeostasis. Professional and non-professional phagocytes achieve the proper recognition, uptake, and degradation of apoptotic cells, a process called efferocytosis. Failure in effero ...

2021

A community-based transcriptomics classification and nomenclature of neocortical cell types

Parviz Ghaderi, Jean Rossier

To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal or glia ...

NATURE PUBLISHING GROUP2020

Model-informed machine learning for multi-component T2 relaxometry

Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Elda Fischi Gomez, Gian Franco Piredda, Thomas Yu, Cristina Granziera, Muhamed Barakovic

Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...

2020

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Henning Paul-Julius Stahlberg

Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human Charcot–Marie–Tooth neuropathy, but the ...

2020

Page 2 of 3

Fractal analysis in the quantification of medical imaging associated with multiple sclerosis pathology

Maria-Alexandra Paun

IMR PRESS2022

Transcranial magnetic stimulation of the brain: What is stimulated? - A consensus and critical position paper

Traian Popa

ELSEVIER IRELAND LTD2022

Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes

Ece Yildiz

WILEY-V C H VERLAG GMBH2022

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Henning Paul-Julius Stahlberg

2020