Concept

Protein microarray

Related publications (139)

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

BACKGROUND: The variety of DNA microarray formats and datasets presently available offers an unprecedented opportunity to perform insightful comparisons of heterogeneous data. Cross-species studies, in particular, have the power of identifying conserved, f ...

BioMed Central2008

Manipulation of magnetic microparticles in liquid phases for on-chip biomedical analysis methods

Ulrike Lehmann

Magnetic microparticles and their application in bioanalytical microfluidic systems have been steadily gaining interest in recent years. This progress is fueled by the comparatively large and long range magnetic forces that can be obtained independently of ...

EPFL2008

Electrospray Micromixer Chip for On-Line Derivatization and Kinetic Studies

Hubert Girault, Niels Erik Lion, Loïc Dayon, Mélanie Abonnenc, Brice Perruche

An electrospray microchip for mass spectrometry comprising an integrated passive mixer to carry out on-chip chemical derivatizations is described. The microchip fabricated using UV-photoablation is composed of two microchannels linked together by a liquid ...

2008

O6-alkylguanine-DNA alkyltransferase as a new tool for functional proteomics

Anke Arnold

Recently the sequencing project of the human genome has been completed. The interest of the post-sequencing-era is shifting nowadays towards the investigation of the biological function and localization of the encoded proteins. Proteins are essential parts ...

EPFL2007

Concept and Demonstration of Individual Probe Actuation in Two-Dimensional Parallel Atomic Force Microscope System

Nico de Rooij, Hans Peter Herzig, Terunobu Akiyama, Peter Vettiger, Laure Aeschimann, André Meister

A concept of an array actuator that is used to control the tip-sample separation of cantilevers in a two-dimensional (2D) probe array scanning system is proposed in this article. The feasibility of the concept is demonstrated with a 10 × 10 array actuator ...

2007

A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression data

Vassily Hatzimanikatis, Eleftherios Papoutsakis

Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, the regulation process in genetic systems is inherently non-linear in nature, a ...

2007

A fully electronic label-free DNA sensor chip

Sandro Carrara, Carlotta Guiducci

This paper presents a microfabricated DNA chip for fully electronic, label-free DNA recognition, based on capacitance measurements. The chip has been fabricated in 0.5-mu m CMOS technology and it features an array of individually addressable sensing sites ...

2007

An oestrogen-dependent model of breast cancer created by transformation of normal human mammary epithelial cells

Cathrin Brisken, Stéphanie Joëlle André, Maryse Fiche

INTRODUCTION: About 70% of breast cancers express oestrogen receptor alpha (ESR1/ERalpha) and are oestrogen-dependent for growth. In contrast with the highly proliferative nature of ERalpha-positive tumour cells, ERalpha-positive cells in normal breast tis ...

2007

Modeling the Isoelectric Focusing of Peptides in an OFFGEL Multicompartment Cell

Hubert Girault, Niels Erik Lion, Hoang-Trang Lam

In proteomic analysis of complex samples at the peptide level (termed shotgun proteomics), an effective prefractionation is crucial to decrease the complexity of the peptide mixture for further analysis. In this perspective, the high-resolving power of the ...

American Chemical Society2007

Functional polymer brushes via surface-initiated controlled radical polymerizations

Stefano Tugulu

The term polymer brush refers to a well defined arrangement of polymer chains, which are tethered with one end to an interface and usually the surface of a solid substrate. Due to steric repulsion the polymer chains furthermore adopt a defined, stretched c ...

EPFL2007

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