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This thesis is the first to be carried out within the framework of the project "Cyberthosis for Paraplegics" in progress at the "Laboratoire de Systèmes Robotiques" (LSRO) of the "Ecole Polytechnique Fédérale de Lausanne" (EPFL). This project, initiated in ...
Acute and long-term (up to 56 days) evolution of geometry, structural properties, vascular smooth muscle (VSM) tone and histomorphometric properties of the rat common carotid arteries under induced hypertension were investigated. Hypertension was induced i ...
This paper addresses evaluation and visualization of stress and strain on soft biological tissues in contact given three-dimensional models of reconstructed organs from magnetic resonance images (MRI), we use an anatomy-based kinematical model combined wit ...
Estimation of the stress distribution in the solder or glue joint between a cantilever and its base, and of the corresponding bending stress distribution in the cantilever. This reports details results of modelling of the stresses in the solder or glue joi ...
The chondrocytes of adult articular cartilage rely upon transport phenomena within their avascular extracellular matrix for many biological activities. Therefore, changes in matrix structure which influence cytokine transport parameters may be an important ...
We report the filling kinetics of different liquids in nanofabricated capillaries with rectangular cross-section by capillary force. Three sets of channels with different geometry were employed for the experiments. The smallest dimension of the channel cro ...
A poly(ethylene glycol) (PEG)-based hydrogel was used as a scaffold for chondrocyte culture. Branched PEG-vinylsulfone macromers were end-linked with thiol-bearing matrix metalloproteinase (MMP)-sensitive peptides (GCRDGPQGIWGQDRCG) to form a three-dimensi ...
In current biological and biomedical research, quantitative endpoints have become an important factor of success. Classically, such endpoints were investigated with 2D imaging, which is usually destructive and the 3D character of tissue gets lost. 3D imagi ...
Chondrocytes depend upon solute transport within the avascular extracellular matrix of adult articular cartilage for many of their biological activities. Alterations to bioactive solute transport may, therefore, represent a mechanism by which cartilage com ...
Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrixes: a combination of integrin-binding sites and substrates for matrix metalloproteinases (MMP) was required to render the n ...