Concept

Cartilage

Related publications (115)

Development of a musculoskeletal model of the knee joint to predict articular contact patterns during a loaded squat movement

Computational models are a current way to study specific behavior of healthy or pathological tissue or the mechanics of joints. Simulating the native anatomical structures and kinematics are two of the most important tasks to achieve reliable results. It i ...

2010

Plasticity of fetal cartilaginous cells

Dominique Pioletti, Corinne Scaletta, Sandra Jaccoud, Aurélie Quintin

Tissue-specific stem cells found in adult tissues can participate to the repair process following injury. However adult tissues, such as articular cartilage and intervertebral disc, have low regeneration capacity, whereas fetal tissues, such as articular c ...

2010

Pattern-Based Sensing of Sulfated Glycosaminoglycans with a Dynamic Mixture of Iron Complexes

Kay Severin

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4'-methyl-2,2'-bipyri ...

Royal Society of Chemistry2010

Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage

Dominique André Rothenfluh

Osteoarthritis (OA) is one of the most common causes of pain and disability. Currently, non-surgical treatment is limited to analgesic and anti-inflammatory drugs, which are not capable of either modifying the disease process or regenerate damaged parts in ...

EPFL2009

Effect of calcification on agarose gel stiffness and integration strength with Bone

Jérôme Hollenstein

The zone of calcified cartilage (ZCC) is critical for the normal attachment of articular cartilage to bone as well as to the biomimetic bioengineering of osteochondral tissue constructs. However, relatively few osteochondral tissue engineering approaches h ...

2009

Soft-tissue viscoelasticity: extension to anisotropy and finite element implementation

Dominique Pioletti, Arne Christian Vogel

Physiological loading result to finite and finite rate of deformations of soft tissues such as ligament, tendons, and the annulus fibrosus of the intervertebral disc. Under these conditions, these soft tissues exhibit viscoelastic effects such as strain-st ...

2009

Fast collision detection methods for joint surfaces

Daniel Thalmann, Ronan Boulic, Ehsan Arbabi

In the recent years medical diagnosis and surgery planning often require the precise evaluation of joint movements. This has led to exploit reconstructed three-dimensional models of the joint tissues obtained from CT or MR Images (for bones, cartilages, et ...

2009

Does hydrogel-cell construct viscoelasticity affect ECM production?

Line Aschwanden

Low back pain is one of the most prevailing medical concerns and can often be associated with the degeneration of the intervertebral disc. This degeneration results in a loss of biological and mechanical properties, especially a loss of viscoelastic proper ...

2009

Preparation and characterization of dense nanohydroxyapatite/PLLA composites

Jacques Lemaître, Sandrine Gay, Saioa Arostegui Aristimuno

Synthetic bone graft substitutes based on PLLA have been largely studied during the past decade. PLLA/hydroxyapatite composites appear as promising materials for large bone defect healing. In this study dense PLLA/nano-hydroxyapatite composites were prepar ...

2009

Polypeptide ligands for targeting cartilage and methods of use thereof

Jeffrey Alan Hubbell, Dominique André Rothenfluh

Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...

2008

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