Concept
Microarray
Related publications (101)
Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
Didier Trono, Julien Léonard Duc, Christina Ernst
RNA-binding proteins are instrumental for post-transcriptional gene regulation, controlling all aspects throughout the lifecycle of RNA molecules. However, transcriptome-wide methods to profile RNA-protein interactions in vivo remain technically challengin ...
2023Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis
Kristin Schirmer, Anze Zupanic
The use of omics is gaining importance in the field of nanoecotoxicology; an increasing number of studies are aiming to investigate the effects and modes of action of engineered nanomaterials (ENMs) in this way. However, a systematic synthesis of the outco ...
AMER CHEMICAL SOC2020MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans
Using an unbiased high-throughput microRNA (miRNA)-silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes, we previously identified 19 miRNAs as putative regulators of skeletal muscle mitochondrial metabol ...
2020Homogeneous multifocal excitation for high-throughput super-resolution imaging
Pierre Gönczy, Suliana Manley, Kyle Michael Douglass, Khalid Ashraf Mohie Ibrahim, Davide Gambarotto, Paul Guichard, Virginie Hamel, Denis Fortun, Niccolo Banterle, Dora Mahecic
Super-resolution microscopies have become an established tool in biological research. However, imaging throughput remains a main bottleneck in acquiring large datasets required for quantitative biology. Here we describe multifocal flat illumination for fie ...
NATURE PUBLISHING GROUP2020Mechanistic insights into AMP-activated protein kinase-dependent gene expression
AMP-activated protein kinase (AMPK) is a fundamental enzyme that controls energy homeostasis, through orchestrating the cellular response to a reduction in energy availability. Under conditions of cellular energy stress AMPK senses the decrease in ATP leve ...
EPFL2019Theoretical foundations of forward feature selection methods based on mutual information
Francisco Santos Paredes Quartin de Macedo
Feature selection problems arise in a variety of applications, such as microarray analysis, clinical prediction, text categorization, image classification and face recognition, multi-label learning, and classification of internet traffic. Among the various ...
ELSEVIER SCIENCE BV2019Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each
Lukas Kühn, Giovanna Ambrosini, Barbara Grisoni-Neupert, Philipp Bucher, Ramona Pauchard-Batschulat, Otto Hagenbüchle
Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...
PUBLIC LIBRARY SCIENCE2018Artificial niche microarrays for identifying extrinsic cell-fate determinants
The complex cellular microenvironment plays an important role in determining cell fate. For example, stem cells located in a microenvironment termed niche integrate a wide variety of extrinsic cues to take distinct fate choices. Capturing this multiple-inp ...
ELSEVIER ACADEMIC PRESS INC2018microRNA biosensors: Opportunities and challenges among conventional and commercially available techniques
As being the most extensively studied, non-coding, evolutionary conserved, post-transcriptional gene regulators of genome, microRNAs (miRNAs) have taken great attention among various disciplines due to their important roles in biological processes and link ...
2018Characterization of cancer stem cell subpopulations from patient-derived xenografts of advanced prostate cancer
Marina Bice Manuela Menna, Markus Germann
Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial response, a fraction of cases manifest progression to castration-resistant prostate cancer. PCa recurrence is possibly due to androgen-independent cancer stem c ...
AMER ASSOC CANCER RESEARCH2018