Concept

Microarray

Related publications (101)

Splicy: a web-based tool for the prediction of possible alternative splicing events from Affymetrix probeset data

BACKGROUND: The Affymetrix technology is nowadays a well-established method for the analysis of gene expression profiles in cancer research studies. However, changes in gene expression levels are not the only way to link genes and disease. The existence of ...

2007

Functional polymer brushes via surface-initiated controlled radical polymerizations

Stefano Tugulu

The term polymer brush refers to a well defined arrangement of polymer chains, which are tethered with one end to an interface and usually the surface of a solid substrate. Due to steric repulsion the polymer chains furthermore adopt a defined, stretched c ...

EPFL2007

Chemical approaches to microarrays and multifunctional protein labeling

India Christina Sielaff

With the human genome and many other eukaryotic and procaryotic genomes sequenced, the interest in life sciences is shifting towards the examination of the function, modification and regulation of the encoded proteins. Proteins are involved in virtually al ...

EPFL2006

Protein function microarrays based on self-immobilizing and self-labeling fusion proteins

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

Protein microarrays are an attractive approach for the high-throughput analysis of protein function, but their impact on proteomics has been limited by the technical difficulties associated with their generation. Here we demonstrate that fusion proteins of ...

2006

Regional and cellular gene expression changes in human Huntington's disease brain

Darlene Goldstein, Mauro Delorenzi, Doris Chau Voo Thu, Thierry Sengstag

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive molecular analysis of the effect of the disease in the human brain has not previously been available. To elucidate the molecular phenotype of HD on a genome- ...

Oxford University Press2006

BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies

Gerardo Turcatti

The tricarboxylate reagent benzene-1,3,5-triacetic acid (BTA) was used to attach 5'-aminated DNA primers and templates on an aminosilanized glass surface for subsequent generation of DNA colonies by in situ solid-phase amplification. We have characterized ...

Oxford University Press2006

Protein-functionalized polymer brushes

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

Understanding and controlling the interactions between synthetic and biol. materials is of great importance for the development of novel materials for a variety of biomedical and bioanal. applications, including for example stents, vascular grafts and prot ...

2005

Proof of concept for microarray-based detection of DNA-binding oncogenes in cell extracts

Philipp Bucher

The function of DNA-binding proteins is controlled not just by their abundance, but mainly at the level of their activity in terms of their interactions with DNA and protein targets. Moreover, the affinity of such transcription factors to their target sequ ...

2005

Protein-Functionalized Polymer Brushes

Harm-Anton Klok, Kai Johnsson, Stefano Tugulu, India Christina Sielaff, Anke Arnold

A new strategy for the prepn. of protein-functionalized polymer brushes is reported, which is based on a combination of surface-initiated atom transfer radical polymn. (ATRP), p-nitrophenyl chloroformate activation of the surface hydroxyl groups, and subse ...

2005

Microarray analysis of VEGF-C responsive genes in human lymphatic endothelial cells

Melody Swartz, Carolyn Yong Pullin

Vascular endothelial growth factor-C (VEGF-C) is considered one of the most important factors influencing lymphatic endothelial cell biology. The goal of this work was to characterize the gene expression response by lymphatic endothelial cells (LECs) to VE ...

2005

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