Concept

Cure

Related publications (8)

Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

Multiple myeloma is a prevalent and incurable disease, despite the development of new and effective drugs. The recent development of chimeric antigen receptor (CAR)T cells has shown impressive results in the treatment of patients with relapsed or refractor ...

FERRATA STORTI FOUNDATION2021

Development of Photocatalysts towards the Visible-Light driven C-Terminal Bioconjugation of Peptides and Proteins

Marion Marie-Agnès Garreau

If small molecules have led to tremendous progress in curing diseases, new therapeutic agents such as peptides or antibody-drugs conjugates have emerged as a highly promising next generation of pharmaceuticals. As for small molecules, their derivatization ...

EPFL2020

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

Most cases of neurodegenerative diseases are sporadic, hindering the use of genetic mouse models to analyze disease mechanisms. Focusing on the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS), we therefore devised a fully humanized coculture ...

2014

Real-time protein aggregation monitoring with a Bloch surface wave-based approach

Hans Peter Herzig, Sara Santi

The misfolding and aggregation of amyloid proteins has been associated with incurable diseases such as Alzheimer's or Parkinson's disease. In the specific case of Alzheimer's disease, recent studies have shown that cell toxicity is caused by solubl ...

Spie-Int Soc Optical Engineering2014

Real-time Protein Aggregation Monitoring with a Bloch Surface Wavebased Approach

Hans Peter Herzig, Elsie Barakat, Sara Santi

Spie-Int Soc Optical Engineering2014

From natural product to marketed drug: the tiacumicin odyssey

Jieping Zhu

The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...

Royal Soc Chemistry2013

Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model

Ming Zhang

Availability of an ultra-short-course drug regimen capable of curing patients with tuberculosis in 2 to 3 mo would significantly improve global control efforts. Because immediate prospects for novel treatment-shortening drugs remain uncertain, we examined ...

2007

Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas

Patrycja Nowak-Sliwinska

Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatmen ...

Polish Academy of Sciences / Acta Biochimica Polonica2002

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