Concept
Kidney
Related publications (56)
Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
Mutations in Bicaudal C1 (BICC1), an RNA binding protein involved in translational regulation, have been associated with cystic kidney disease both in humans and in mice. Since kidney cysts associate with pancreatic defects in several human syndromes, we i ...
EPFL2015Regulation of the mRNA silencing activity of Bicaudal-C
Cilia dysfunction is a common factor underlying left-right axis malformation and the pathogenesis of virtually all known renal cystic diseases. Mutations in the RNA-binding protein Bicaudal-C (Bicc1) provoke cystic kidneys reminiscent of polycystic kidney ...
EPFL2015Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System
Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Mouti Elodie Mouloungui
Ureteral replacement by tissue engineering might become necessary following tissue loss after excessive ureteral trauma, after retroperitoneal cancer, or even after failed reconstructive surgery. This need has driven innovation in the design of novel scaff ...
Mary Ann Liebert, Inc2015Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression
Daniel Constam, Dmitri Firsov, Séverine Marguerite Urfer, Florian Urs Bernet
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are in advanced clinical development, early diagnos ...
BioMed Central2015Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
Daniel Constam, Jacques Rougemont, Anne Grapin-Botton, Joan Goulley, Laurence Anne E Lemaire, Yung Hae Kim
In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads to left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed i ...
Company Of Biologists Ltd2015Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury
Grégoire Courtine, Rubia van den Brand, Daniel Eberli
Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...
Elsevier Science Inc2013Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury
Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity. The purpose of this ...
American Society for Clinical Investigation2013Surface characteristics of acrylic modified polysulfone membranes improves renal proximal tubule cell adhesion and spreading
Current polyvinylpyrrolidone-modified polysulfone (PVP-PSU) membranes in haemodialysers do not facilitate the attachment and proliferation of renal proximal tubule cells (RPTCs) For bioartificial kidney (BAK) development expensive extracellular matrices ar ...
2011