Amazon RiverThe Amazon River (ˈæməzən, ˈæməzɒn; Río Amazonas, Rio Amazonas) in South America is the largest river by discharge volume of water in the world, and the disputed longest river system in the world in comparison to the Nile. The headwaters of the Apurímac River on Nevado Mismi had been considered for nearly a century the Amazon basin's most distant source until a 2014 study found it to be the headwaters of the Mantaro River on the Cordillera Rumi Cruz in Peru.