Dumbo | EPFL Graph Search

Dumbo is a 1941 American animated fantasy film produced by Walt Disney Productions and released by RKO Radio Pictures. The fourth Disney animated feature film, it is based upon the storyline written by Helen Aberson and Harold Pearl, and illustrated by Helen Durney for the prototype of a novelty toy ("Roll-a-Book"). The main character is Jumbo Jr., an elephant who is cruelly nicknamed "Dumbo", as in "dumb". He is ridiculed for his big ears, but in fact he is capable of flying by using his ears as wings. Throughout most of the film, his only true friend, aside from his mother, is the mouse, Timothy – a relationship parodying the stereotypical animosity between mice and elephants. Made to recoup the financial losses of both Pinocchio and Fantasia, Dumbo was a deliberate pursuit of simplicity and economy for the Disney studios. At 64 minutes, it is one of Disney's shortest animated features. Sound was recorded conventionally using the RCA System. One voice was synthesized using the Sonovox system, but it, too, was recorded using the RCA System. Dumbo was released on October 23, 1941, where it was met with critical acclaim directed towards its story, humor, visuals and music. However, it has also been criticized for racist stereotyping of black people. Among the film’s lifetime accolades include an Academy Award for Best Scoring of a Musical Picture. In 2017, the film was selected for preservation in the United States National Film Registry by the Library of Congress as being "culturally, historically and aesthetically significant". In the years following its release, Dumbo has enjoyed enduring popularity. Its derivative works include a popular theme park attraction, merchandise, a television series, and a live-action adaptation. While a large circus spends the off-season in the "Winter Grounds" in Florida, a flock of white storks delivers babies to the animals. One elephant, Mrs. Jumbo, does not receive her baby, and keeps scanning the sky. The circus sets out on a new tour, and a belated stork catches up with the moving train and drops off the expected baby elephant, Jumbo Junior.

Elucidating the role of Hmx1 during mouse development

Linda Bapst

This thesis focuses on the study of H6 homeobox 1 (HMX1) gene, a homeobox-containing transcription factor involved in sensory organ and eye development and responsible for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti. The purpose of my study is to better understand the mechanism and role of this transcription factor. My thesis is divided into three parts. The first part proposes a predictive promoter model approach to identify new HMX1 target gene. The second part concerns an animal model of Hmx1 mutation, the dumbo mouse model, and brings a new insight into lethal craniofacial defects. The third part concerns the characterization of the visual capacity of the dumbo mice and a description of a new pattern of vision-linked defects. In the first part we propose a predictive promoter model approach based on transcriptomic analysis of post-natal day 15 mouse retina from dumbo and wild type mouse. This method revealed that Sgcg, Tshz2 and Slc6a9 were Hmx1 targets in the mouse retina. Ptpro, Sema3f, and Epha6 belong to the retinal axon guidance pathway and play an important role in retinotopic mapping. Significant enrichment of HMX1 binding site confirmed this pathway and we validated the transcriptional activity of Hmx1 on Ptpro, Sema3f and Sgcg by Luciferase assay. In the second part of the project we investigate the dumbo mouse model, carrying a stop codon in Hmx1, and representing the first animal model for the oculo-auricular syndrome of Schorderet-Munier-Franceschetti. The homozygous Hmx1dmbo is a semi-lethal mutation and stillborns present severe craniofacial defects, including cleft palate, chest defect and bone hypoplasia of maxilla, zygomatic process, mandible and frontal. In the third part of the thesis we provide a complete description of the vision in dumbo mouse. Despite a normal retinal phenotype, the vision of this mouse is completely impaired. We demonstrate that this was caused by abnormal retinotopic mapping and optic nerve hypoplasia. In dumbo mice the retinal ganglion cells axon projections failed to target the visual output, namely the dorsal lateral geniculate nucleus and the superior colliculus, and present abnormal patterning.

EPFL2015

Elucidating the role of Hmx1 during mouse development

Linda Bapst

EPFL2015