Concept
Gene pool
Related publications (32)
Meeting our Makers:Uncovering the cis-regulatory activity of transposable elements using statistical learning
The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...
EPFL2024Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
BackgroundIt is generally accepted that most evolutionary transformations at the phenotype level are associated either with rearrangements of genomic regulatory elements, which control the activity of gene networks, or with changes in the amino acid conten ...
2023Unexpected post‐glacial colonisation route explains the white colour of barn owls ( Tyto alba ) from the British Isles
Nicolas Jean Philippe Guex, Christian Iseli
The climate fluctuations of the Quaternary shaped the movement of species in and out of glacial refugia. In Europe, the majority of species followed one of the described traditional postglacial recolonization routes from the southern peninsulas towards the ...
2022Genetic signatures of divergent selection in European beech (Fagus sylvatica L.) are associated with the variation in temperature and precipitation across its distribution range
High genetic variation and extensive gene flow may help forest trees with adapting to ongoing climate change, yet the genetic bases underlying their adaptive potential remain largely unknown. We investigated range-wide patterns of potentially adaptive gene ...
WILEY2021Confounding factors from inducible systems for spatiotemporal gene expression regulation
Johan Auwerx, Richardus Houtkooper
Spatiotemporally regulated targeted gene manipulation is a common way to study the effect of gene variants on phenotypic traits, but the Cre/loxP and Tet-On/Tet-Off systems can affect whole-organism physiology and function due to off-target effects. We hig ...
ROCKEFELLER UNIV PRESS2020Evaluating Alternative Metacommunity Hypotheses for Diatoms in the McMurdo Dry Valleys Using Simulations and Remote Sensing Data
Diatoms are diverse and widespread freshwater Eukaryotes that make excellent microbial subjects for addressing questions in metacommunity ecology. In the McMurdo Dry Valleys of Antarctica, the simple trophic structure of glacier-fed streams provides an ide ...
2020Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro
Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...
NATURE PUBLISHING GROUP2019Identifying gene function and module connections by the integration of multispecies expression compendia
Johan Auwerx, Kristina Schoonjans, Stephan Morgenthaler, Hao Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Daria Rukina, Qingyao Huang, Yang Li, Changmyung Oh, Andrea Komljenovic
The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...
Cold Spring Harbor Laboratory2019Similarities and differences in the regulation of HoxD genes during chick and mouse limb development
Denis Duboule, Lucille Delisle, Guillaume Andrey, Leonardo Beccari, Christopher Chase Bolt, Nayuta Yakushiji
In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then the dis ...
PUBLIC LIBRARY SCIENCE2018Multiscale landscape genomic models to detect signatures of selection in the alpine plant Biscutella laevigata
Stéphane Joost, Kevin Leempoel
Plant species are known to adapt locally to their environment, particularly in mountainous areas where conditions can vary drastically over short distances. The climate of such landscapes being largely influenced by topography, using fine-scale models to e ...
2018