Concept
Penumbra (medicine)
Related publications (25)
Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke
Friedhelm Christoph Hummel, Philipp Johannes Koch
BACKGROUND:The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at the group level in clinical trials, many patients remain sev ...
Philadelphia2023Enabling Stroke Theranostics with Hyperpolarized Magnetic Resonance
The severe social and economic burden of stroke is a strong motivation for the exploration of innovative medical approaches. In this context, magnetic resonance (MR) of hyperpolarized (HP) molecular agents via dissolution dynamic nuclear polarization (dDNP ...
EPFL2023Deep Learning Building on Prior Ischemic Core Segmentation Improves Prediction of Infarction After Stroke
Dimitri Nestor Alice Van De Ville, Elisabeth Anne Dirren, Guillaume Paul Olivier Leclerc
Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely used to identify the acute ischemic core and penumbra, but the prediction of the final infarct remains challenging. With the advent o ...
LIPPINCOTT WILLIAMS & WILKINS2021Integrating regional perfusion CT information to improve prediction of infarction after stroke
Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Elisabeth Anne Dirren
Physiological evidence suggests that neighboring brain regions have similar perfusion characteristics (vascular supply, collateral blood flow). It is largely unknown whether integrating perfusion CT (pCT) information from the area surrounding a given voxel ...
SAGE PUBLICATIONS INC2020Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
Myocardial ischemia reperfusion (I/R) injury contributes to almost half of the necrotic area after myocardial infarction. To date there is no approved drug to prevent or reduce myocardial I/R injury. The study and understanding of the pathophysiological me ...
JOURNAL OF VISUALIZED EXPERIMENTS2018Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury
Pierre Magistretti, Jocelyne Bloch
Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. Design: Prospec ...
LIPPINCOTT WILLIAMS & WILKINS2018Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo
Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...
EPFL2017Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation
Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective str ...
Frontiers Media Sa2017A Robotic System for Quantitative Assessment and Poststroke Training of Forelimb Retraction in Mice
Silvestro Micera, Stefano Lai, Marco Mainardi
Background. Neurorehabilitation protocols based on the use of robotic devices have recently shown to provide promising clinical results. However, their efficacy is still limited because of the poor comprehension of the mechanisms at the basis of functional ...
Sage Publications Inc2014Treatment with Evasin-3 reduces atherosclerotic vulnerability for ischemic stroke, but not brain injury in mice
Nikolaos Stergiopoulos, Katia Galan, Luciano Dos Santos Aggum Capettini, Jean-Christophe Copin, Danielle Gomes Passos Silva
Neutrophilic inflammation might have a pathophysiological role in both carotid plaque rupture and ischemic stroke injury. Here, we investigated the potential benefits of the CXC chemokine-binding protein Evasin-3, which potently inhibits chemokine bioactiv ...
Nature Publishing Group2013