Publications related to Hydrocyanation

Isocyanoacetates as Synthetic Platform Towards Natural Products and Biologically Relevant Scaffolds

My PhD work started with the development of a racemic access to trigonoliimine B, an hexacyclic alkaloid isolated in 2010. After having explored different strategies, we reported a 7-step synthesis of this natural product. This synthesis features a challen ...

EPFL2014

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone

Qian Wang, Jieping Zhu, Thomas Bertrand Pascal Marie Buyck

Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for closing the seven ...

Schweizerische Chemische Gesellschaft2014

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Nicolai Cramer, Laetitia Marie Mélanie Souillart

The lactone motif is ubiquitous in natural products and pharmaceuticals. The Tishchenko disproportionation of two aldehydes, a carbonyl hydroacylation, is an efficient and atom-economic access to lactones. However, these reaction types are limited to the t ...

Wiley-Blackwell2014

Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors

Pablo Rivera Fuentes, Matthias Rottmann, Jose Enrico Quijano Quinsaat, Céline Freymond

A series of aryl nitrile-based ligands were prepd. to investigate the effect of their electrophilicity on the affinity against the cysteine proteases rhodesain and human cathepsin L. D. functional theory calcns. provided relative reactivities of the nitril ...

2012

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

Yury Tsybin, Matthew Wodrich, Konstantin Zhurov, Hisham Ben Hamidane, Aleksey Vorobyev

Mass spectrometry techniques employing electron capture and electron transfer dissociation represent powerful approaches for the analysis of biological samples. Despite routine employment in analytical fields, the underlying physical processes dictating pe ...

Amer Chemical Soc2012

Hierarchical Assembly and Reticulation of Two-Dimensional Mn- and Ni-TCNQ(x) (x=1, 2,4) Coordination Structures on a Metal Surface

Klaus Kern, Sebastian Stepanow, Tzu-Chun Tseng, Nasiba Abdurakhmanova

We report a scanning tunneling microscopy (STM) investigation of the self-assembly of two-dimensional metal-organic coordination networks comprised of Mn or Ni atoms (M) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) molecules on a Ag(100) surface. The growth ...

2011

An advanced calibration process for a thermo-hydro-mechanical triaxial system

Lyesse Laloui, Alessio Ferrari, Ali Seiphoori

This paper presents an innovative double cell triaxial system developed for better understanding of the complex thermo-hydro-mechanical behaviour of soils. In addition to the conventional triaxial mechanical testing, the equipment is aimed to perform sucti ...

2011

Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Christian Hartinger, Yuehui Li, Xuemei Yang, Ilaria Biondi, Yugang Cui, Manish Chaubey, Cinzia Chiappe

Nitrile-functionalized pyrrolidinium-based ionic liqs. were prepd. and characterized by spectroscopic methods and x-ray crystallog. The application of these new ionic liqs. as reaction media for Suzuki and Stille C-C cross-coupling reactions was studied an ...

Royal Society of Chemistry2010

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Hydrocyanation

"New methods for indoles and [3,4]-fused oxindoles syntheses" and "Copper-catalyzed/mediated difunctionalization of alkenes with alkylnitriles"

Isocyanoacetates as Synthetic Platform Towards Natural Products and Biologically Relevant Scaffolds

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

Engineering of highly efficient tetrahydroquinoline sensitizers for dye-sensitized solar cells

Hierarchical Assembly and Reticulation of Two-Dimensional Mn- and Ni-TCNQ(x) (x=1, 2,4) Coordination Structures on a Metal Surface

An advanced calibration process for a thermo-hydro-mechanical triaxial system

Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs

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Chat with Graph Search

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of α-Aryl-α-isocyanoacetate to Vinyl Phenyl Selenone

"New methods for indoles and [3,4]-fused oxindoles syntheses" and "Copper-catalyzed/mediated difunctionalization of alkenes with alkylnitriles"

Isocyanoacetates as Synthetic Platform Towards Natural Products and Biologically Relevant Scaffolds

Highly Enantioselective Rhodium(I)-Catalyzed Carbonyl Carboacylations Initiated by C-C Bond Activation

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

Tuning and predicting biological affinity: aryl nitriles as cysteine protease inhibitors

An advanced calibration process for a thermo-hydro-mechanical triaxial system

Engineering of highly efficient tetrahydroquinoline sensitizers for dye-sensitized solar cells

Nitrile-functionalized pyrrolidinium ionic liquids as solvents for cross-coupling reactions involving in situ generated nanoparticle catalyst reservoirs

Hierarchical Assembly and Reticulation of Two-Dimensional Mn- and Ni-TCNQ(x) (x=1, 2,4) Coordination Structures on a Metal Surface