Publications related to Shiga toxin

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...

2021

Mammalian membrane trafficking as seen through the lens of bacterial toxins

Françoise Gisou van der Goot Grunberg, Francisco De Magalhães Sarmento R De Mesquita, Oksana Andrei Sergeeva

A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...

WILEY2020

Mechanisms protecting host cells against bacterial pore-forming toxins

Francisco De Magalhães Sarmento R De Mesquita

Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by generating stable protein pores, which allow uncontrolled exchanges between the extracellula ...

SPRINGER BASEL AG2019

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Oliver Hantschel, Nadine Eliane Schmit, Katyayanee Neopane

Monobodies are small engineered binding proteins that, upon expression in cells, can inhibit signaling of cytosolic oncoproteins with outstanding selectivity. Efficacy may be further increased by inducing degradation of monobody targets through fusion to t ...

2019

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

Bruno Lemaitre, Florent François Masson, Juan Camilo Paredes Escobar, Mario Gonzalo Garcia Arraez

BackgroundInsects frequently live in close relationship with symbiotic bacteria that carry out beneficial functions for their host, like protection against parasites and viruses. However, in some cases, the mutualistic nature of such associations is put in ...

2019

Mechanism of Shiga Toxin Clustering on Membranes

Julian Charles Shillcock

The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, despite th ...

American Chemical Society2017

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

Julian Charles Shillcock

The bacterial Shiga toxin is composed of an enzymatically active A-subunit, and a receptor-binding homopentameric B-subunit (STxB) that mediates intracellular toxin trafficking. Upon STxB-mediated binding to the glycolipid globotriaosylceramide (Gb3) at th ...

Royal Society of Chemistry2016

Pore-forming toxins: ancient, but never really out of fashion

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and have long fascinated structural biologists, microbiologists and immunologists. Interestingly, pore-forming proteins with remarkably similar structures to PFTs are fou ...

Nature Publishing Group2016

The Ins and Outs of Anthrax Toxin

Françoise Gisou van der Goot Grunberg

Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-gamma-D-glutamic a ...

Mdpi Ag2016

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Shiga toxin

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia

Mammalian membrane trafficking as seen through the lens of bacterial toxins

Mechanisms protecting host cells against bacterial pore-forming toxins

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

Mechanism of Shiga Toxin Clustering on Membranes

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

Pore-forming toxins: ancient, but never really out of fashion

The Ins and Outs of Anthrax Toxin

Graph Chatbot

Chat with Graph Search

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Mechanisms protecting host cells against bacterial pore-forming toxins

Identification of a Dps contamination in Mitomycin-C–induced expression of Colicin Ia

Mammalian membrane trafficking as seen through the lens of bacterial toxins

Functional analysis of RIP toxins from the Drosophila endosymbiont Spiroplasma poulsonii

Targeted protein degradation through cytosolic delivery of monobody binders using bacterial toxins

Pore-forming toxins: ancient, but never really out of fashion

Mechanism of Shiga Toxin Clustering on Membranes

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

The Ins and Outs of Anthrax Toxin