Concept

Warburg effect (oncology)

Related publications (66)

Altered Glycogen Metabolism in Cultured Astrocytes from Mice with Chronic Glutathione Deficit; Relevance for Neuroenergetics in Schizophrenia

Pierre Magistretti, Igor Allaman, Kim Do, Jean-Marie Petit

Neurodegenerative and psychiatric disorders including Alzheimer's, Parkinson's or Huntington's diseases and schizophrenia have been associated with a deficit in glutathione (GSH). In particular, a polymorphism in the gene of glutamate cysteine ligase modul ...

Public Library of Science2011

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Arnaud Comment

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme ...

2011

In Vivo Evidence for Lactate as a Neuronal Energy Source

Pierre Magistretti, Renaud Jolivet

Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the past decade, a role for lactate in fueling the energetic requirements of neurons has emerged. Furt ...

2011

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Rolf Gruetter, João Miguel das Neves Duarte

Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose ...

Wiley-Blackwell2009

Sustained neuronal activation raises oxidative metabolism to a new steady-state level: Evidence from 1H NMR spectroscopy in the human visual cortex

Rolf Gruetter

To date, functional 1H NMR spectroscopy has been utilized to report the time courses of few metabolites, primarily lactate. Benefiting from the sensitivity offered by ultra-high magnetic field (7 T), the concentrations of 17 metabolites were measured in th ...

2007

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

2005

On-line biomass monitoring with scanning dielectric spectroscopy

Urs von Stockar, Ian William Marison, Sergio Valentinotti, Christopher Cannizzaro

Accurate online monitoring of biomass is an enduring problem. Of the various methods available, one of the more satisfactory is with dielec. spectroscopy (often referred to as capacitance monitoring). However, as this technique measures total -biovolume', ...

2003

Production of Sm37-GAPDH, a major therapeutical target in human schistosomiasis

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in the glycolytic metabolism and the production of energy. This probably explains why GAPDH was evidenced as a major therapeutical target in several parasitic diseases; either as a vaccine ca ...

Wiley-Blackwell2000

The coupling between catabolism and anabolism of Methanobacterium thermoautotrophicum in H2- and iron-limited continuous cultures

Urs von Stockar, Ian William Marison

The aim of the present work was to investigate whether uncoupling of catabolism from anabolism, which was often obsd. in heterotrophic microorganisms under energy-sufficient growth conditions, also occurs in the autotrophic bacterium M. thermoautotrophicum ...

1999

Mid-infrared spectroscopic monitoring of animal cell culture bioreactor processes

Urs von Stockar, Ian William Marison, Martin Rhiel

Mid-IR (MIR) spectroscopy in combination with partial least-squares (PLS) regression anal. was used to monitor the concns. of glucose, lactate, ammonia, and asparagine in situ during bioreactor cultivation of CHO/SSF3 cells. Simple PLS calibration models w ...

1999

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