Publications related to Statin

Membrane specificity of the human cholesterol transfer protein STARD4

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Academic Press Ltd- Elsevier Science Ltd2024

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Jacques Fellay, Christian Axel Wandall Thorball, Stéphane Fournier, Roxane De La Harpe

Lay Summary The aim of this study is to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores currently recommended by European and US guidelines on cardiovas ...

OXFORD UNIV PRESS2023

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

Christopher Clark, Mehdi Gholam

Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may interfere with ...

CELL PRESS2023

Sufficient Cause Interaction for Time-to-event Outcomes

Mats Julius Stensrud, Pal Christie Ryalen

Methods to assess sufficient cause interactions are well developed for binary outcomes. We extend these methods to handle time-to-event outcomes, which occur frequently in medicine and epidemiology. Based on theory for marginal structural models in continu ...

2019

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Henning Paul-Julius Stahlberg, Melanie Zechner

ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance. Although many inhibitors and modulators of ABCG2 have been developed, understanding ...

Springer Nature2018

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Olivier Martin, Gerardo Turcatti, Nicolas Jean Philippe Guex, Marc Chambon

The Wnt pathway, which controls crucial steps of the development and differentiation programs, has been proposed to influence lipid storage and homeostasis. In this paper, using an unbiased strategy based on high-content genome-wide RNAi screens that monit ...

Nature Publishing Group2015

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Kristina Schoonjans, Alessia Perino

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

Emerging Pharmacological Treatments to Prevent Abdominal Aortic Aneurysm Growth and Rupture

Nikolaos Stergiopoulos, Bram Trachet

Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established dru ...

Bentham Science Publ Ltd2015

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Statin

Squalene Depletion in Skin Following Human Exposure to Ozone under Controlled Chamber Conditions

Membrane specificity of the human cholesterol transfer protein STARD4

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

Sufficient Cause Interaction for Time-to-event Outcomes

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Emerging Pharmacological Treatments to Prevent Abdominal Aortic Aneurysm Growth and Rupture

Graph Chatbot

Chat with Graph Search

Squalene Depletion in Skin Following Human Exposure to Ozone under Controlled Chamber Conditions

Membrane specificity of the human cholesterol transfer protein STARD4

Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice

Plant sterols and cholesterol metabolism are associated with five-year cognitive decline in the elderly population

Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study

Sufficient Cause Interaction for Time-to-event Outcomes

Emerging Pharmacological Treatments to Prevent Abdominal Aortic Aneurysm Growth and Rupture

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance