Concept

Protein aggregation

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Protein aggregation

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Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis

Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis

Establishing the links between Aβ aggregation and cytotoxicity in vitro using biophysical approaches

A Close Look at Proteins: Submolecular Resolution of Two- and Three-Dimensionally Folded Cytochrome c at Surfaces

Multidimensional View of Amyloid Fibril Nucleation in Atomistic Detail

Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Mechanisms of LRRK2-Mediated Neurodegeneration

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells