Concept
Antibiotic
Related publications (250)
Recent advances in therapeutic targets identification and development of treatment strategies towards Pseudomonas aeruginosa infections
The opportunistic human pathogen Pseudomonas aeruginosa is the causal agent of a wide variety of infections. This non-fermentative Gram-negative bacillus can colonize zones where the skin barrier is weakened, such as wounds or burns. It also causes infecti ...
BMC2023Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots
Francesco Stellacci, Inyoung Yonah Lee
Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...
ROYAL SOC CHEMISTRY2022Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Henning Paul-Julius Stahlberg, Dongchun Ni, Iwan Zimmermann, Denis Bucher
Lipopolysaccharides are major constituents of the extracellular leaflet in the bacterial outer membrane and form an effective physical barrier for environmental threats and for antibiotics in Gram-negative bacteria. The last step of LPS insertion via the L ...
2022Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening
Uropathogenic Escherichia coli (UPEC) are the most common bacterial pathogens causing urinary tract infections (UTIs). Driven by the development of antibiotic resistant UPEC strains, UTIs have become a major public health issue and generate substantial hea ...
EPFL2022Natural competence of the pathogen Acinetobacter baumannii: an elusive phenomenon
Natural competence for transformation is an important driver of horizontal DNA exchange between different organisms. This can result in accumulation of dangerous genetic features, such as antibiotic resistance genes, in a single organism. One example of an ...
EPFL2022Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions
Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...
EPFL2022Two defence systems eliminate plasmids from seventh pandemic Vibrio cholerae
Melanie Blokesch, David William Adams, Milena Jadwiga Jaskolska
Horizontal gene transfer can trigger rapid shifts in bacterial evolution. Driven by a variety of mobile genetic elements—in particular bacteriophages and plasmids—the ability to share genes within and across species underpins the exceptional adaptability o ...
2022A systematic CRISPR approach to understanding the role of Drosophila antimicrobial peptides in immunity in vivo
Antimicrobial peptides (AMPs) are host-encoded antibiotics that combat invading microbes. These short immune effectors are conserved in plants, animals, and fungi. Early work showed that AMPs killed bacteria in generalist fashions in vitro: i.e. AMPs that ...
EPFL2022Ozonation of organic compounds in water and wastewater: A critical review
Ozonation has been applied in water treatment for more than a century, first for disinfection, later for oxidation of inorganic and organic pollutants. In recent years, ozone has been increasingly applied for enhanced municipal wastewater treatment for eco ...
PERGAMON-ELSEVIER SCIENCE LTD2022Probing the growth and mechanical properties of Bacillus subtilis biofilms through genetic mutation strategies
Bacterial communities form biofilms on various surfaces by synthesizing a cohesive and protective extracellular matrix, and these biofilms protect microorganisms against harsh environmental conditions. Bacillus subtilis is a widely used experimental specie ...
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