Publications related to Somatic evolution in cancer

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Paul Joseph Dyson, Zhaofu Fei, Peng Huang

Multi-layered single-walled carbon nanotubes, t ermed SWNT@BSA@Au-S-PEG -FA@DOX, which int egrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and eut single-walled carbon na ...

2018

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Elisa Oricchio, Daniele Tavernari, Mohammad Sadegh Saghafinia, Elena Battistello, Stephanie Jocelyne Sungalee, Franck Claude Raynaud, Giovanni Ciriello, Marco Mina, Titouan Laessle

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Paolo Angelino, Etienne Meylan, Mauro Delorenzi, Alessandra Piersigilli, Jawahar Kopparam, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates

Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel, Agnese Petrini

A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [CpM(DBM/ HDB/AVB)Cl] and [CpM(DBM/HDB/AVB)(PTA)]-[SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydi- ...

American Chemical Society2017

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Etienne Meylan, Ferdinando Pucci, Julien Robert Rémi Faget

Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly unders ...

Amer Assoc Advancement Science2017

Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?

Adrien Raphaël Depeursinge

Purpose In the context of oropharyngeal cancer treated with definitive radiotherapy, the aim of this retrospective study was to identify the best threshold value to compute metabolic tumor volume (MTV) and/or total lesion glycolysis to predict local-region ...

Lippincott Williams & Wilkins2017

Allosteric cross-talk in chromatin can mediate drug-drug synergy

Paul Joseph Dyson, Ursula Röthlisberger, Tina Riedel, Giulia Palermo

Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated ...

2017

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

Paul Joseph Dyson, Zhaofu Fei

Combining doxorubicin with thermal therapy in the clinic has led to startling results in the treatment of problematic cancers. Here, we describe a multimo dal multi-walled carbon nanotube material that combines tumor targeting, doxorubicin delivery, and ph ...

Royal Soc Chemistry2017

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Somatic evolution in cancer

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Monobodies as possible next-generation protein therapeutics - a perspective

Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?

Allosteric cross-talk in chromatin can mediate drug-drug synergy

KRAB'n'KAP, DNA methylation and epigenetic memory

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy

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Chat with Graph Search

Monobodies as possible next-generation protein therapeutics - a perspective

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Allosteric cross-talk in chromatin can mediate drug-drug synergy

KRAB'n'KAP, DNA methylation and epigenetic memory

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates

Metabolic Tumor Volume and Total Lesion Glycolysis in Oropharyngeal Cancer Treated With Definitive Radiotherapy: Which Threshold Is the Best Predictor of Local Control?

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Stepwise growth of gold coated cancer targeting carbon nanotubes for the precise delivery of doxorubicin combined with photothermal therapy