Publications related to Leukemia

NUP214-ABL1 mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

Oliver Hantschel

The NUP214-ABL1 fusion protein is a constitutively active protein tyrosine kinase that is found in 6% of patients with T-cell acute lymphoblastic leukemia and that promotes proliferation and survival of T-lymphoblasts. Although NUP214-ABL1 is sensitive to ...

Pensiero Scientifico / Ferrata Storti Foundation2014

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

Sebastian Maerkl, Jean-Bernard Nobs

Although Schyzosaccharomyces pombe is one of the principal model organisms for studying the cell cycle, surprisingly few methods have characterized S. pombe growth on the single cell level, and no methods exist capable of analyzing thousands of cells and t ...

Public Library of Science2014

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Application of mild hyperthermia can increase the cytotoxicity of anticancer drugs in tumour cells. In this report, we describe low molecular weight thermoactive ruthenium-based drugs with fluorous chains that are selectively triggered by mild hyperthermia ...

2014

A Control Flow Prototype for a Dose Recommending Device for Chronic Myeloid Leukemia Patients

Giovanni De Micheli, Alena Simalatsar, Wenqi You Dubout, Dechao Sun

In this paper we present a prototype of a control flow for an a posteriori drug dose adaptation for Chronic Myelogenous Leukemia (CML) patients. The control flow is modeled using Timed Automata extended with Tasks (TAT) model. The feedback loop of the cont ...

2013

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Freddy Radtke, Anne Wilson

Hematopoietic stem cells (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for self-renewal and differentiation. Notch signals are essential for the emergence of definitive hematopoiesis in mouse embryos and are ...

American Society of Hematology2013

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

Oliver Hantschel

Constitutive activation of STAT5 is critical for the maintenance of chronic myeloid leukemia (CML) characterized by the BCR-ABL oncoprotein. Tyrosine kinase inhibitors (TKIs) for the STAT5-activating kinase JAK2 have been discussed as a treatment option fo ...

Nature Publishing Group2012

The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

Oliver Hantschel

The BCR-ABL fusion kinase is the driving mutation of chronic myelogenous leukemias and is also expressed in a subset of acute lymphoblastic leukemias. Recent advances in elucidating the structure, regulation, and signaling of BCR-ABL have led to the identi ...

Amer Assoc Cancer Research2012

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

Olivier Martin, Christian Santschi, Shourya Dutta Gupta

Hydrogen peroxide (H2O2) is known to play a multifaceted role in cell physiology mechanisms involving oxidative stress and intracellular signal transduction. Therefore, the development of analytical tools providing information on the dynamics of H2O2 gener ...

Spie-Int Soc Optical Engineering, Po Box 10, Bellingham, Wa 98227-0010 Usa2012

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Leukemia

NUP214-ABL1 mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

A Control Flow Prototype for a Dose Recommending Device for Chronic Myeloid Leukemia Patients

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

Nilotinib as frontline and second-line therapy in chronic myeloid leukemia: open questions

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

Notch in T-ALL: new players in a complex disease

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Chat with Graph Search

Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

A Control Flow Prototype for a Dose Recommending Device for Chronic Myeloid Leukemia Patients

Thermoresponsive organometallic arene ruthenium complexes for tumour targeting

Biophotonic tool for sensing the dynamics of H2O2 extracellular release in stressed cells

The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL

NUP214-ABL1 mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

Nilotinib as frontline and second-line therapy in chronic myeloid leukemia: open questions

Notch in T-ALL: new players in a complex disease