Concept
Ryanodine receptor
Related publications (47)
Structural heterogeneity of the ion and lipid channel TMEM16F
Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...
Berlin2024Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity
Johan Auwerx, Umberto De Marchi
Sustained ryanodine receptor (RyR) Ca2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training ...
NATURE PORTFOLIO2021Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal Zn(II), resultin ...
FUTURE SCI LTD2020Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo
Andreas Wiederkehr, Umberto De Marchi, Nicolas Bouche, Christophe Boss, Federico Sizzano, Mouna Conrad
The development of cell-based biosensors that give insight into cell and tissue function in vivo is an attractive technology for biomedical research. Here, the development of a cell line expressing a fluorescent calcium sensor for the study of beta-cell fu ...
Wiley2017Triclosan Impairs Swimming Behavior and Alters Expression of Excitation-Contraction Coupling Proteins in Fathead Minnow (Pimephales promelas)
Triclosan (TCS), a high volume chemical widely used in consumer products, is a known aquatic contaminant found in fish inhabiting polluted watersheds. Mammalian studies have recently demonstrated that TCS disrupts signaling between the ryanodine receptor ( ...
American Chemical Society2013Mathematical modeling and numerical simulation of excitation-contraction phenomena in the heart
In this Master thesis we aim at studying some physiological and computational aspects of the excitation-contraction mechanisms in the heart muscle. This phenomenon exhibits many complexities at different spatio-temporal scales. The relevance and applicabil ...
2013Ultrafast Ca2+ wave in cultured vascular smooth muscle cells aligned on a micropatterned surface
Jean-Jacques Meister, Jean-Louis Bény, Benoît Vianay, Jairo Camilo Quijano Perez
Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is regulated by cytosolic Ca2+ concentration (Ca2+) which propagates as Ca2+ waves over a sign ...
Elsevier2013Intercellular ultrafast calcium wave in vascular smooth muscle cells
Communication between vascular smooth muscle cells (SMCs) allows control of their contraction and so regulation of blood flow. The contractile state of SMCs is controled by cytosolic Ca2+ concentration ([Ca2+]i) which propagates as Ca2+ waves over a signif ...
EPFL2013Functionalized 3D 7x20-array of vertically stacked SiNW FET for streptavidin sensing
Mihai Adrian Ionescu, Montserrat Fernandez-Bolanos Badia, Elizabeth Buitrago Godinez
A 3D, vertically stacked silicon nanowire (SiNW) field effect transistor (FET) featuring a high density array (7×20) of fully depleted channels has been successfully fabricated by a CMOS compatible process on silicon on insulator (SOI) and functionalized f ...
IEEE2013Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by Connexin43
Jean-Jacques Meister, Jean-Louis Bény, Nadia Halidi
Intercellular Ca2+ wave propagation between vascular smooth muscle cells (SMCs) is associated with the propagation of contraction along the vessel. Here, we characterize the involvement of gap junctions (GJs) in Ca2+ wave propagation between SMCs at the ce ...
2012