Publications related to Lymphedema

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Mauro Delorenzi, Alexis Rapin, Dominique Velin, Esther Bovay, François Renevey

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...

NATURE PUBLISHING GROUP2020

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Nikolaos Stergiopoulos, Marco Pisano, Melody Swartz, Valentina Triacca

Objective: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected ti ...

W B SAUNDERS CO LTD2019

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Marco Pisano, Melody Swartz, Witold Waldemar Kilarski

Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...

Springer2019

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Olivier Michielin, Melody Swartz, Manuel Andreas Fankhauser, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Esther Danenberg, Timothy Murray

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) ...

TAYLOR & FRANCIS INC2018

Multiple roles of lymphatic vessels in peripheral lymph node development

Borja Prat Luri, Esther Bovay, Ann-Helen Willrodt

The mammalian lymphatic system consists of strategically located lymph nodes (LNs) embedded into a lymphatic vascular network. Mechanisms underlying development of this highly organized system are not fully understood. Using highresolution imaging, we show ...

2018

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Marco Pisano, Melody Swartz, Witold Waldemar Kilarski, Esra Güç, Valentina Triacca

Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lippincott Williams & Wilkins2017

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Nicola Harris, Lalit Kumar Dubey, Praneeth Karempudi

Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LT beta R) signalin ...

Springer Nature2017

Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges

Melody Swartz, Lambert Charles François Potin

Lymphatic vessels are the primary route of communication from peripheral tissues to the immune system; as such, they represent an important component of local immunity. In addition to their transport functions, new immunomodulatory roles for lymphatic vess ...

Elsevier Science Bv2017

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Lymphedema

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Multiple roles of lymphatic vessels in peripheral lymph node development

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges

Graph Chatbot

Chat with Graph Search

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Elucidating the role of lymphatic vessels within the tumor microenvironment of breast cancer

Multiple roles of lymphatic vessels in peripheral lymph node development

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Lymphatic vessel density is associated with CD8(+) T cell infiltration and immunosuppressive factors in human melanoma

Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges