Concept
Upper motor neuron
Related publications (32)
Trio preserves motor synapses and prolongs motor ability during aging
Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Greta Limoni, Samuel William Vernon, Wei Jiao
The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...
Cell Press2024Uncovering interactions between Descending Neurons as a functional principle of behavioural control
Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...
EPFL2024Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Henry Markram, Rodrigo de Campos Perin
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per fear memory engram. However, how the local network within the LA processes this information and w ...
Nature Portfolio2024Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial
Background Each year, five million people are left disabled after stroke. Upper -extremity (UE) dysfunction is a leading problem. Neuroplasticity can be enhanced by non-invasive brain stimulation (NIBS) but evidence from large, randomized multicenter trial ...
Elsevier2024The mouse motor system contains multiple premotor areas and partially follows human
Valerio Zerbi, Joanes Grandjean
While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher -order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we sho ...
Cell Press2024Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates
The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...
SOC NEUROSCIENCE2023Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord
The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...
EPFL2023Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas
An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...
EPFL2023Of mice and men: Increased dendritic complexity gives rise to unique human networks
Henry Markram, Kathryn Hess Bellwald, Lida Kanari, Ying Shi, Idan Segev, Alexis Arnaudon, Jay Coggan, Ruth Benavides Piccione, Natali Barros Zulaica
The organizational principles that distinguish the human brain from those of other species have been a long-standing enigma in neuroscience. Here, we leverage advances in algebraic topology to uncover the structural properties of the human brain at subcell ...
bioRxiv2023