Concept

Narcolepsy

Related publications (28)

Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

Pierre Magistretti, Jean-Marie Petit, Maxime Olivier Baud

Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentatio ...

Wiley-Blackwell2016

Motor Performance Is not Enhanced by Daytime Naps in Older Adults

Friedhelm Christoph Hummel, Winifried Backhaus

The impact of sleep on motor learning in the aging brain was investigated using an experimental diurnal nap setup. As the brain ages several components of learning as well as motor performance change. In addition, aging is also related to sleep architectur ...

2016

Implications of the interplay between light and dark for human health in the built environment

Marilyne Andersen, María Lovísa Ámundadóttir

24-hour cycles of light and dark are one of the most significant factors in the built environment that affect human health and wellbeing. In addition to stimulating visual responses, light induces a range of circadian, physiological and behavioral response ...

2015

Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

Hilal Lashuel, Klodjan Stafa, Simona Eleuteri

Parkinson's disease (PD) is a common neurodegenerative disorder. Functional interactions between some PD genes, like PINK1 and parkin, have been identified, but whether other ones interact remains elusive. Here we report an unexpected genetic interaction b ...

2015

Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies

Philippe Renaud, Anja Kunze, Yufei Ren

Compartmentalized microfluidic devices are designed to engineer the cellular environment for cell cultures. The practical use of the compartmentalized chambers can be expanded to induce co-pathological cell cultures, where one cell population expresses a s ...

Springer New York2015

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders

Damien Lapray

Insomnia is a serious medical and social problem, its prevalence in the general population ranges from 9 to 35% depending on the country and assessment method. Often, patients are subject to inappropriate and therefore dangerous pharmacotherapies that incl ...

Cambridge Univ Press2014

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Grégoire Courtine, Isabel Laura Vollenweider

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...

Elsevier2014

Principal component structuring of the Non-REM sleep EEG spectrum in older adults yields age-related changes in the sleep and wake drives

Mirjam Münch

Age-related disturbances of the sleep-wake cycle can reflect ontogenetic changes in regulatory mechanisms underlying normal and pathological aging, but the exact nature of these changes remains unclear. The present report is the first attempt to apply prin ...

2013

The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes

Pierre Magistretti, Jean-Marie Petit, Joël Gyger, Xinhe Liu

Sleep wake cycle is characterized by changes in neuronal network activity. However, for the last decade there is increasing evidence that neuroglial interaction may play a role in the modulation of sleep homeostasis and that astrocytes have a critical impa ...

Elsevier2013

Evidence that the Lunar Cycle Influences Human Sleep

Endogenous rhythms of circalunar periodicity (similar to 29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1, 2]. In contrast, there is a great deal of folklore but no consistent association o ...

Elsevier2013

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