Concept
Myelin
Related publications (96)
Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Tobias Kober, Tom Hilbert, Gian Franco Piredda
BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...
Amer Soc Neuroradiology2024A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...
Nature Portfolio2024Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
Gioele La Manno, Zahra Moslehi, Nina-Lydia Kazakou
The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...
BMC2023Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions
Silvestro Micera, Maria Pasquini
Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly unde ...
SOC NEUROSCIENCE2023Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles
Alexey Sapozhnik, Samuel Jones
JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population. In rare cases of severe immune suppression, the virus is able to establish a lytic infectio ...
Washington2023A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length
Silvestro Micera, Francesco Iberite
Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A nov ...
WILEY2023Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces
The peripheral nervous system (PNS) regulates the exchange of sensory information andmotor commands between the body and the central nervous system. Further, through theautonomic nervous system, the PNS plays a pivotal role in controlling vital physiologic ...
EPFL2023Enhancement of brain atlases with region-specific coordinate systems: flatmaps and barrel column annotations
Michael Reimann, Sirio Bolaños Puchet, Aleksandra Zuzanna Teska
Digital brain atlases define a hierarchy of brain regions and their locations in three-dimensional space. They provide a standard coordinate system in which diverse datasets can be integrated for visualization and analysis. They also enable building of dat ...
2023Does powder averaging remove dispersion bias in diffusion MRI diameter estimates within real 3D axonal architectures?
Marco Pizzolato, Tim Bjørn Dyrby
Noninvasive estimation of axon diameter with diffusion MRI holds the potential to investigate the dynamic properties of the brain network and pathology of neurodegenerative diseases. Recent studies use powder averaging to account for complex white matter a ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Signatures of life course socioeconomic conditions in brain anatomy
Maria del Carmen Sandi Perez, Bogdan Draganski
Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the bra ...
2022