Concept
Human parainfluenza viruses
Related publications (56)
De novo protein design enables the precise induction of RSV-neutralizing antibodies
Luciano Andres Abriata, Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Jaume Bonet Martinez, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers, Elie Charles Eugène Dheilly, Mélanie Evelyne Villard, Yujia Wang
De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remain ...
2020Control of Waterborne Human Viruses by Indigenous Bacteria and Protists Is Influenced by Temperature, Virus Type, and Microbial Species
Tamar Kohn, Anna Carratala Ripolles, Margot Ninon Lauren Olive
Human viruses are ubiquitous contaminants in surface waters, where they can persist over extended periods of time. Among the factors governing their environmental persistence, the control (removal or inactivation) by microorganisms remains poorly understoo ...
2020Expanding beyond the natural protein repertoire to engineer targeted vaccines and diagnostics
Proteins have evolved over millions of years to carry out the vast majority of biological functions that are fundamental to life. Their three-dimensional structures and functions have been in the focus of biomedical research for many decades, and substanti ...
EPFL2019Microorganisms from surface waters contribute to the inactivation of human echovirus 11: toward biocontrol of viral pathogens?
Tamar Kohn, Anna Carratala Ripolles, Margot Ninon Lauren Olive
Human viruses are widespread as contaminants in surface waters and represent a significant health risk. Viral pathogens can persist in aquatic ecosystems and cause infections via contaminated water or food. Among the different factors governing the environ ...
2019Proxies to monitor the inactivation of viruses by ozone in surface water and wastewater effluent
Urs von Gunten, Tamar Kohn, Camille Wolf, Annalisa Pavese
Ozone treatment is an effective barrier against viral pathogens, therefore it is an integral part of many water and wastewater treatment trains. However, the efficacy of ozone treatment remains difficult to monitor, due to the lack of methods to track viru ...
2019Inactivation of waterborne viruses by ozone: Kinetics and mechanisms
The growing world population, in conjunction with climate change, cases the global water de-mand to increase. It is, therefore, crucial to protect existing water resources from chemical pollution and contamination by pathogens. An increasingly popular stra ...
EPFL2019Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen
Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Jaume Bonet Martinez, Sai Reddy, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory syncytial virus [RSV], influenza, dengue, and others) have resisted vaccine development efforts, largely ...
2019Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha 7 mediated nuclear import pathway
Jaume Bonet Martinez, Sebastian Beck
Influenza A viruses are able to adapt to restrictive conditions due to their high mutation rates. Importin-alpha 7 is a component of the nuclear import machinery required for avian-mammalian adaptation and replicative fitness in human cells. Here, we eluci ...
WILEY2019Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism
Francesco Stellacci, Paulo Henrique Jacob Silva, Ahmet Bekdemir, Valeria Cagno, Emma-Rose Janecek, Samuel Thomas Jones, Marie Mueller
Viral infections kill millions yearly. Available antiviral drugs are virus-specific and active against a limited panel of human pathogens. There are broad-spectrum substances that prevent the first step of virus–cell interaction by mimicking heparan sulfat ...
2018Identifying the role of complex I in organohalide respiration of Firmicutes
Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin
Organohalide-respiring bacteria (OHRB) are capable to link energy conservation with the use of organohalide compounds as terminal electron acceptors. While obligate OHRB relies only on this process for growing, facultative OHRB are able to use alternative ...
2018