Concept

Microbiota

Related publications (91)

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Nicola Harris, Benjamin John Marsland, Tina Herbst

RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...

2011

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

Bruno Lemaitre, Nichole Broderick, Sveta Chakrabarti

Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely u ...

2009

Influence of environmental factors on the structures of bacterial communities in a chloroethene – contaminated aquifer

Christof Holliger, Pierre Rossi, Noam Shani

Numerous industries have been using chloroethenes (CEs), mainly tetrachloroethene and trichloroethene, as non-flammable solvents since the beginning of the 20th century. Massive usage, along with careless handling and storage, made CEs one of the most abun ...

2009

Limited diffusive fluxes of substrate facilitate coexistence of two competing bacterial strains

Dani Or

Soils are known to support a great bacterial diversity down to the millimeter scale, but the mechanisms by which such a large diversity is sustained are largely unknown. A feature of unsaturated soils is that water usually forms thin, poorly-connected film ...

Blackwell Publishing Ltd, Oxford2008

Mechanisms of neonatal mucosal antibody protection

Nicola Harris, Andrew J. Macpherson

Following an abrupt transition at birth from the sterile uterus to an environment with abundant commensal and pathogenic microbes, neonatal mammals are protected by maternal Abs at mucosal surfaces. We show in mice that different Ab isotypes work in distin ...

2006

Interactions between commensal intestinal bacteria and the immune system

Nicola Harris, Andrew J. Macpherson

Although we might shudder at the thought of billions of bacteria living in our lower intestine, we are colonized by these passengers shortly after birth. However, the relationship is mostly of mutual benefit, and they shape our immune system throughout lif ...

2004

Impacts of heavy metal contamination and phytoremediation on a microbial community during a twelve-month microcosm experiment

Fabienne Gremion

The effects of heavy metals and phytoextraction practices on a soil microbial Community were studied during 12 months using a hyperaccumulating plant (Thlaspi caerulcseens) grown in an artificially contaminated soil. The 16S ribosomal RNA genes of the Bact ...

Blackwell Publishing Ltd, Oxford2004

Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis

Bart Deplancke

Necrotic enteritis (NE) is a worldwide poultry disease caused by the alpha toxin-producing bacterium Clostridium perfringens. Disease risk factors include concurrent coccidial infection and the dietary use of cereal grains high in nonstarch polysaccharides ...

2003

The functions of mucosal T cells in containing the indigenous commensal flora of the intestine

Nicola Harris, Andrew J. Macpherson

There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised of the si ...

2002

Microbial modulation of innate defense: goblet cells and the intestinal mucus layer

Bart Deplancke

The gastrointestinal epithelium is covered by a protective mucus gel composed predominantly of mucin glycoproteins that are synthesized and secreted by goblet cells. Changes in goblet cell functions and in the chemical composition of intestinal mucus are d ...

2001

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