Publications related to Poly (ADP-ribose) polymerase

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

The aggregation of intracellular tau protein is a major hallmark of Alzheimer's disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present an in-d ...

NATURE PUBLISHING GROUP2018

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Johan Auwerx, Carlos Canto Alvarez, Joanna Ratajczak

NAD(+) is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD(+) precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide ribosi ...

Nature Publishing Group2016

No DDRama at chromosome ends: TRF2 takes centre stage

Antonio Porro, Liuh-Yow Chen, Sascha Feuerhahn

Telomeres are nucleoprotein structures capping the natural termini of eukaryotic linear chromosomes. Telomeres possess an inherent ability to circumvent the activation of a full-blown DNA damage response (DDR), and hence fusion reactions, by limiting inapp ...

Elsevier Science London2015

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Norman Lionel Moullan, Hongbo Zhang, Eija Riitta Pirinen, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Elsevier2014

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Joachim Lingner, Antonio Porro, Sascha Feuerhahn

Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular senescenc ...

Elsevier2014

Functional characterization of the TERRA transcriptome at damaged telomeres

Joachim Lingner, Jacques Rougemont, Antonio Porro, Julien Delafontaine, Sascha Feuerhahn

Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellul ...

Nature Publishing Group2014

Deleterious effect of homogeneous and heterogeneous near-neutral photo-Fenton system on Escherichia coli. Comparison with photo-catalytic action of TiO2 during cell envelope disruption

César Pulgarin, Andrzej Sienkiewicz, Cristina del Socorro Lonfat

The mechanisms underlying bacterial inactivation by solar photo-Fenton at near-neutral pH have not yet been investigated in detail. In particular, no consensus exists on the bacterial inactivation mechanism under solar light enhanced by the Fenton's reagen ...

Elsevier Science Bv2014

Molecular basis of telomere syndrome caused by CTC1 mutations

Joachim Lingner, Jana Majerská, Liuh-Yow Chen

Mutations in CTC1 lead to the telomere syndromes Coats Plus and dyskeratosis congenita (DC), but the molecular mechanisms involved remain unknown. CTC1 forms with STN1 and TEN1 a trimeric complex termed CST, which binds ssDNA, promotes telomere DNA synthes ...

Cold Spring Harbor Laboratory Press2013

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Poly (ADP-ribose) polymerase

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors

Telomeric states in cancer development

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

No DDRama at chromosome ends: TRF2 takes centre stage

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres

Functional characterization of the TERRA transcriptome at damaged telomeres

Deleterious effect of homogeneous and heterogeneous near-neutral photo-Fenton system on Escherichia coli. Comparison with photo-catalytic action of TiO2 during cell envelope disruption

Molecular basis of telomere syndrome caused by CTC1 mutations

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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

No DDRama at chromosome ends: TRF2 takes centre stage

The telomeric DNA damage response: Insights into telomere compaction and identification of novel damage signaling factors

Functional characterization of the TERRA transcriptome at damaged telomeres

Molecular basis of telomere syndrome caused by CTC1 mutations

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Deleterious effect of homogeneous and heterogeneous near-neutral photo-Fenton system on Escherichia coli. Comparison with photo-catalytic action of TiO2 during cell envelope disruption

TERRA-Reinforced Association of LSD1 with MRE11 Promotes Processing of Uncapped Telomeres