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Explores replicative immortality in cancer cells, focusing on telomere erosion, telomerase activity, and the role of p53 in maintaining genomic stability.
Explores the development and challenges of antibody-based therapeutics, including chimeric and humanized antibodies, alternative scaffolds, and in vitro selection.
Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.
Covers DNA damage types, repair mechanisms, UV-induced damage, survival curves, NER deficiency consequences, tumor suppressor genes, and cancer prevention.
Explores DNA repair mechanisms, focusing on BER and NER, cellular responses to DNA damage, and genetic disorders impacting DNA repair and cancer susceptibility.
Explores how inflammation promotes tumor growth and immunosuppression, focusing on the role of inflammatory cells like MDSCs and neutrophils in the tumor microenvironment.
