Concept

Hydrogenase

Related publications (46)

Green oxidation catalysts: computational design of high-efficiency models of galactose oxidase

Ab initio calcns. were used for the rational design of efficient alc. oxidn. catalysts that mimic the enzyme galactose oxidase. Different ligand substitutions were explored based on natural (copper, depicted) and alternative (rhodium) metal redox centers. ...

2004

Network of hydrogenase maturation in Escherichia coli: role of accessory proteins HypA and HybF

Melanie Blokesch

We have studied the roles of the auxiliary protein HypA and of its homolog HybF in hydrogenase maturation. A mutation in hypA leads to the nearly complete blockade of maturation solely of hydrogenase 3 whereas a lesion in hybF drastically but not totally r ...

2002

Maturation of [NiFe]-hydrogenases in Escherichia coli: the HypC cycle

Melanie Blokesch

Carbamoyl phosphate (CP) has been implicated as an educt for the synthesis of the CO and CN ligands of the metal centre of [NiFe]-hydrogenases in Escherichia coli, since CP synthetase mutants (carAB) are unable to generate active hydrogenases due to a bloc ...

2002

Metal insertion into NiFe-hydrogenases

Melanie Blokesch

The synthesis and the insertion of the metallocentre of NiFe-hydrogenases is a complex process, in which seven maturation enzymes plus ATP, GTP and carbamoyl phosphate are involved. The review summarizes what is known about the properties and activities of ...

2002

Fidelity of metal insertion into hydrogenases

Melanie Blokesch

The fidelity of metal incorporation into the active center of hydrogenase 3 from Escherichia coli was studied by analyzing the inhibition of the maturation pathway by zinc and other transition metals. Hydrogenase maturation of wild-type cells was significa ...

2001

Interplay between the specific chaperone-like proteins HybG and HypC in maturation of hydrogenases 1, 2, and 3 from Escherichia coli

Melanie Blokesch

The hybG gene product from Escherichia coli has been identified as a chaperone-like protein acting in the maturation of hydrogenases 1 and 2. It was shown that HybG forms a complex with the precursor of the large subunit of hydrogenase 2. As with HypC, whi ...

2001

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