Concept

Bone marrow

Related publications (332)

Complex metastatic niches: already a target for therapy?

Metastatic spread is an inefficient process which requires generation of supportive microenvironments in which cancer cells can survive, proliferate and escape from immune attack. These niches are induced by systemic and locally produced factors and establ ...

Elsevier2014

Translation of biomechanical concepts in bone tissue engineering: from animal study to revision knee arthroplasty

Dominique Pioletti, Alexandre Terrier, Brigitte Jolles-Haeberli, Alireza Roshan Ghias

Bone defects in revision knee arthroplasty (RKA) are often located in load-bearing regions. The goal of this study was to determine if a physiologic load could be used as an in situ osteogenic signal to the scaffolds filling the bone defects. In order to a ...

Taylor & Francis2014

Notch1 regulates angio-supportive bone marrow-derived cells in mice: relevance to chemoresistance

Freddy Radtke

Host responses to chemotherapy can induce resistance mechanisms that facilitate tumor regrowth. To determine the contribution of bone marrow-derived cells (BMDCs), we exposed tumor-bearing mice to chemotherapeutic agents and evaluated the influx and contri ...

American Society of Hematology2013

Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization

Irène Baccelli

The phosphatase and tumor suppressor PTEN inhibits the phosphoinositol-3-kinase (PI3K) signaling pathway and plays a key role in cell growth, proliferation, survival, and migration. Pten conditional deletion using MxCre or Scl-CreERT leads to splenomegaly ...

Rockefeller Univ Press2013

LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance

Freddy Radtke, Anne Wilson

Hematopoietic stem cells (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for self-renewal and differentiation. Notch signals are essential for the emergence of definitive hematopoiesis in mouse embryos and are ...

American Society of Hematology2013

Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Sandrine Gerber, Françoise Borcard, Céline Marie Anne Journot, Phally Kong

Surface functionalization of hydroxyapatite (HA) and β-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible co ...

Swiss Chemical Soc2013

Epiphyseal Chondro-Progenitor Cell Therapy For Articular Cartilage Regeneration

Salim Elias Darwiche

Articular cartilage regeneration poses particularly tough challenges for implementing cell-based therapies. Many cell types have been investigated looking for a balanced combination of responsiveness and stability, yet techniques are still far from definin ...

EPFL2013

Intravital Immunofluorescence for Visualizing the Microcirculatory and Immune Microenvironments in the Mouse Ear Dermis

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Jeremy Teo, Scott Oliver

Visualizing the dynamic behaviors of immune cells in living tissue has dramatically increased our understanding of how cells interact with their surroundings, contributing important insights into mechanisms of leukocyte trafficking, tumor cell invasion, an ...

Public Library of Science2013

Role of the bile acid membrane receptor TGR5 in macrophages and metabolism

Mitsunori Nomura

Activation of the bile acid responsive G protein-coupled receptor TGR5 improves metabolic homeostasis via induction of energy expenditure and release of glucagon-like peptide-1 (GLP-1). The goal of my PhD work was to explore the role of macrophage TGR5 wit ...

EPFL2013

Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment

Jeffrey Alan Hubbell, Mikaël Martino

While human bone morphogenetic protein-2 (rhBMP-2) is a promising growth factor for bone regeneration, its clinical efficacy has recently shown to be below expectation. In order to improve the clinical translation of rhBMP-2, there exists strong motivation ...

Elsevier2013

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