Concept

Bone marrow

Related publications (332)

Detraining effects on the mechanical properties and morphology of rat tibiae

Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Pierre-François Leyvraz

To study bone adaptation to detraining in growing rats, nine weeks-old immature female Wistar rats (n=110) were subjected to treadmill running programs (30 or 60 minutes-a-day) for up to 15 weeks, followed by unrestricted cage activities for the subsequent ...

2004

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Anne Wilson

The activity of adult stem cells is essential to replenish mature cells constantly lost due to normal tissue turnover. By a poorly understood mechanism, stem cells are maintained through self-renewal while concomitantly producing differentiated progeny. He ...

2004

Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells

Michele De Palma

Gene-based delivery can establish a sustained supply of therapeutic proteins within the nervous system. For diseases characterized by extensive CNS and peripheral nervous system (PNS) involvement, widespread distribution of the exogenous gene may be requir ...

American Society for Clinical Investigation2004

Fetal bone cells for tissue engineering

Dominique Pioletti, Corinne Scaletta, Pierre-François Leyvraz

We envision the use of human fetal bone cells for engineered regeneration of adult skeletal tissue. A description of their cellular function is then necessary. To our knowledge, there is no description of human primary fetal bone cells treated with differe ...

2004

Orthopedic implants used as drug delivery systems

Bastian Peter

Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...

EPFL2004

Processing of porous polymer composites for bone tissue engineering

Bone is a natural cellular composite, with a gradient structure going from a loose interconnected core to an outer dense wall, thus minimising bone weight while maintaining a high mechanical performance. Bone can be repaired using either auto- or allo- gra ...

EPFL2004

Optimal femoral head contour segmentation in CT images using dynamic programming

Charles Baur, Gaëtan Marti

We present a new contour segmentation method for femoral head detection in CT images. The principal idea underlying our approach is to represent the contour using active rays. Each ray has internal energy (continuity and smoothness constraints), as well as ...

2004

Can the increase of bone mineral density following bisphosphonates treatments be explained by biomechanical considerations?

Dominique Pioletti, Lalaonirina Rakotomanana Ravelonarivo

OBJECTIVE: We hypothesized that bone mineral density increase following bisphosphonates treatments may be explained by the influence of the drug on the mechanical bone remodeling parameters. BACKGROUND: Patients treated with bisphosphonates continuously in ...

2004

Immediate implant placement using injectable calcium phosphate hydraulic cement in dogs

Jacques Lemaître, Pascale Van Landuyt

Techniques allowing implant placement in extraction sockets require either high diameter implants in surgically enlarged sockets or grafting and/or regenerative procedures around implants after their primary surgical stabilization. This study aimed to eval ...

2004

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

Michele De Palma

Angiogenic tumor vessels are promising targets for the activity and the selective delivery of cancer therapeutics. The bone marrow contributes different cell types to the tumor stroma, including hematopoietic cells and, as recently suggested, vascular endo ...

Nature Publishing Group2003

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