Concept

Granulation tissue

Related publications (36)

Survey of volatile oxylipins and their biosynthetic precursors in bryophytes

Oxylipins are metabolites which are derived from the oxidative fragmentation of polyunsaturated fatty acids. These metabolites play central roles in plant hormonal regulation and defense. Here we survey the production of volatile oxylipins in bryophytes an ...

2010

Development of a medical instrument to induce and control hydrogel polymerization in-situ

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser

Background - Nucleus pulposus degeneration is a very common musculo-skeletal pathology, which is in part responsible for low back pain, a pandemic medical problem. Artificial hydrogels are being investigated by research group around the world for the purpo ...

2010

Biomechanical regulation of blood vessel growth during tissue vascularization

Witold Waldemar Kilarski

Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. Us ...

2009

Cadherins establish mechano-resistant junctions between fibrogenic fibroblasts

Philippe Pittet

During wound healing and in a variety of fibrocontractive diseases, fibroblasts differentiate into contractile myofibroblasts by acquiring stress fibers and by expressing α-smooth muscle actin (α-SMA). Myofibroblasts of wound granulation tissue, in contras ...

EPFL2008

Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity

Boris Hinz, Michael David Martin

During wound healing and fibrocontractive diseases fibroblasts acquire a smooth muscle cell-like phenotype by differentiating into contractile force generating myofibroblasts. We examined whether regulation of myofibroblast contraction in granulation tissu ...

Wiley-Blackwell2006

The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila

Bruno Lemaitre

Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is co ...

Wiley-Blackwell2006

Bone diagnostic instrument

Georg Fantner

The bone diagnostic instrument is designed to measure materials properties of bone even if it is covered with soft tissue such as periosteum, connective tissue and skin. It uses (1) a probe assembly, consisting of a reference probe that penetrates soft tis ...

2006

Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro

Melody Swartz, Boris Hinz

The differentiation of fibroblasts to contractile myofibroblasts, which is characterized by de novo expression of alpha-smooth muscle actin (alpha-SMA), is crucial for wound healing and a hallmark of tissue scarring and fibrosis. These processes often foll ...

Company of Biologists2005

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes

Jean-Jacques Meister, Boris Hinz

Myofibroblasts are specialized fibroblasts that contribute to wound healing by producing extracellular matrix and by contracting the granulation tissue. They appear in a phase of wound healing when the dermis strongly interacts with activated epidermal ker ...

Schattauer2004

Myofibroblast development is characterized by specific cell-cell adherens junctions

Jean-Jacques Meister, Boris Hinz, Philippe Pittet, Josiane Angèle Charlotte Smith-Clerc

Myofibroblasts of wound granulation tissue, in contrast to dermal fibroblasts, join stress fibers at sites of cadherin-type intercellular adherens junctions (AJs). However, the function of myofibroblast AJs, their molecular composition, and the mechanisms ...

American Society for Cell Biology2004

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