Concept

Morphogenesis

Related publications (82)

PPARgamma in human and mouse physiology

The peroxisome proliferator activated receptor gamma (PPARgamma) is a member in the nuclear receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on gene expression. As PPARgamma also coordinates adipocyte differentiatio ...

2007

Interstitial flow and its effects in soft tissues

Melody Swartz, Mark Fleury

Interstitial flow plays important roles in the morphogenesis, function, and pathogenesis of tissues. To investigate these roles and exploit them for tissue engineering or to overcome barriers to drug delivery, a comprehensive consideration of the interstit ...

2007

A driving force for change: interstitial flow as a morphoregulator

Melody Swartz, Joseph Rutkowski

Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients throughout the tissue, but also has important roles in tis ...

Elsevier2007

beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells

P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate ...

2007

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism

Melody Swartz, Federica Boschetti, Mark Fleury

Cell organization is largely orchestrated by extracellular gradients of morphogenetic proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular matrix, but the mechanisms by which it and other matrix-bound morphogens are m ...

2005

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud

Freddy Radtke

The Notch family of receptors is involved in a wide variety of developmental processes, including cell fate specification, cell proliferation, and cell survival decisions during cell differentiation and tissue morphogenesis. Notch1 and Notch ligands are ex ...

2005

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

Cathrin Brisken

Mammary glands, like other skin appendages such as hair follicles and teeth, develop from the surface epithelium and underlying mesenchyme; however, the molecular controls of embryonic mammary development are largely unknown. We find that activation of the ...

2004

Signaling in morphogenesis: transport cues in morphogenesis

Melody Swartz

Extracellular transport processes play critical roles in morphogenesis. While diffusive transport effects on morphogenesis are well illustrated in examples like blood capillary architecture and in cell morphogenetic responses to the local extracellular pro ...

2003

A Morphogenetic Evolutionary System: Phylogenesis of the POEtic Circuit

Dario Floreano, Claudio Mattiussi, Daniel Roggen

This paper describes a new evolutionary mechanism developed specifically for cellular circuits. Called morphogenetic system, it is inspired by the mechanisms of gene expression and cell differentiation found in living organisms. It will be used as the phyl ...

2003

beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis

The lungs are divided, both structurally and functionally, into two distinct components, the proximal airways, which conduct air, and the peripheral airways, which mediate gas exchange. The mechanisms that control the specification of these two structures ...

2003

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