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This review sums up the activity in the field of in situ product removal in whole cell bioprocesses over the last 20 yr. It gives a complete summary of ISPR operations with microbial cells and cites a series of interesting ISPR applications in plant and an ...
TThe synthesis and properties of a novel set of building blocks for the preparation of self-assembling biomaterials are described. These molecules consist of a relatively short oligo(L-lactic acid)n segment (n̄ = 10-40) that is substituted with a cholester ...
PURPOSE: To investigate the potential use of polymeric nanoparticles for the delivery of antisense oligonucleotides in HIV-1-infected cell cultures. METHODS: Phosphorothioate oligonucleotides were encapsulated into poly (D,L-lactic acid) nanoparticles. Two ...
A new class of molecules for the preparation of self-assembling biomaterials were synthesized. These molecules consist of a cholesteryl-moiety attached via an oligo(ethylene oxide) or oligo(L-lactic acid) segment to a biologically relevant headgroup. The o ...
This report describes the synthesis and supramolecular organization of a novel class of linear-dendritic block copolymers. The molecules, which are termed rodcoil dendrons, consist of a cholesterol moiety that is attached to L-lysine dendrons of three diff ...
Optimal control of fed-batch fermenters S. Valentinotti† C. Cannizzaro‡ M.Rhiel‡ U. Holmberg† U. von Stockar‡ D. Bonvin† †Institut d’Automatique, EPFL, 1015 Lausanne, Switzerland ‡Institut de Genie Chimique, EPFL, 1015 Lausanne, Switzerland Fermentors are ...
Crabtree neg. organisms such as Kluyveromyces, Pichia, Hansenula and Candida, are used to make selected org. products such as lactic acid. The organisms are cultured in a first culture medium that includes glucose, under conditions that promote cellular re ...
An in vitro model, designated the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), was used to study the effect of a soygerm powder rich in beta-glycosidic phytoestrogenic isoflavones on the fermentation pattern of the colon microbiota and to ...
Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...
Accurate online monitoring of biomass is an enduring problem. Of the various methods available, one of the more satisfactory is with dielec. spectroscopy (often referred to as capacitance monitoring). However, as this technique measures total -biovolume', ...