A poikilotherm (ˈpɔɪkələˌθɜrm,_pɔɪˈkɪləˌθɜrm) is an animal whose internal temperature varies considerably. Poikilotherms have to survive and adapt to environmental stress. One of the most important stressors is temperature change, which can lead to alterations in membrane lipid order and can cause protein unfolding and denaturation at elevated temperatures. It is the opposite of a homeotherm, an animal which maintains thermal homeostasis. While the term in principle can apply to all organisms, it is generally only applied to animals, and mostly to vertebrates. Usually the fluctuations are consequence of variation in the ambient environmental temperature. Many terrestrial ectotherms are poikilothermic. However some ectotherms remain in temperature-constant environments to the point that they are actually able to maintain a constant internal temperature and are considered homeothermic. It is this distinction that often makes the term "poikilotherm" more useful than the vernacular "cold-blooded", which is sometimes used to refer to ectotherms more generally.
Poikilothermic animals include types of vertebrate animals, specifically some fish, amphibians, and reptiles, as well as many invertebrate animals. The naked mole-rat and sloth are some of the rare mammals which are poikilothermic.
The term derives from Greek poikilos (ποικίλος), meaning "varied," ultimately from a root meaning "dappled" or “painted,” and thermos (θερμός), meaning "heat".
Poikilotherm animals must be able to function over a wider range of temperatures than homeotherms. The speed of most chemical reactions vary with temperature, and in order to function poikilotherms may have four to ten enzyme systems that operate at different temperatures for an important chemical reaction. As a result, poikilotherms often have larger, more complex genomes than homeotherms in the same ecological niche. Frogs are a notable example of this effect, though their complex development is also an important factor in their large genome.