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Wnt signals control decisive steps in development and can induce the formation of tumors. Canonical Wnt signals control the formation of the embryonic axis, and are mediated by stabilization and interaction of beta-catenin with Lef/Tcf transcription factor ...
Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...
We have identified by two-dimensional polyacrylamide gel electrophoresis a protein known as stathmin which is phosphorylated in a time- and concentration-dependent manner in response to brain-derived neurotrophic factor (BDNF) in primary cultures of cortic ...
Under particular circumstances like lactation and fasting, the blood-borne monocarboxylates acetoacetate, beta-hydroxybutyrate, and lactate represent significant energy substrates for the brain. Their utilization is dependent on a transport system present ...
The pentose phosphate pathway and the pyruvate shunt were identified as major pathways of glucose catabolism in a recombinant, riboflavin-producing Bacillus subtilis strain. Reactions connecting the tricarboxylic acid cycle and glycolysis, catalyzed by the ...
The amt. of Vitreoscilla Hb (VHb) expression was modulated over a broad range with an isopropyl-beta-D-thiogalactopyranoside- (IPTG)- inducible plasmid, and the consequences on microaerobic Escherichia coli physiol. were examd. in glucose fed-batch cultiva ...
In order to investigate the formation and the time evolution of Na oxidation states, a thin ayer 0 sodium was deposited on oxidized substrates and exposed to oxygen at 10(-9) Torr. In the Na 2p core-level spectrum, several chemically shifted components hav ...
The aim of the present work was to investigate whether uncoupling of catabolism from anabolism, which was often obsd. in heterotrophic microorganisms under energy-sufficient growth conditions, also occurs in the autotrophic bacterium M. thermoautotrophicum ...
A review with 55 refs. Oxygen is a key substrate in animal cell metab. It has been reported that the oxygen uptake rate (OUR) is a good indicator of cellular activity, and even under some conditions, a good indicator of the no. of viable cells. The measure ...
To study intramitochondrial phospholipid flow, radiolabeled phosphatidylserine was introduced into isolated rat liver mitochondria from donor vesicles through the action of a nonspecific lipid transfer protein. Imported phosphatidylserine was rapidly decar ...
American Society for Biochemistry and Molecular Biology1992