Concept
Substrate-level phosphorylation
Related publications (116)
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
Hilal Lashuel, Nadine Aït Bouziad, Anass Chiki, Galina Limorenko
The microtubule-associated protein Tau is implicated in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease. Increasing evidence suggests that post-translational modifications play critical roles in regulating Tau's norma ...
2020Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic plasticity and behavioral deficits in AD is not known. Here, we show that th ...
CELL PRESS2020Characterization of the Mercapturic Acid Pathway, an Important Phase II Biotransformation Route, in a Zebrafish Embryo Cell Line
Kristin Schirmer, Alena Tierbach
In view of the steadily increasing number of chemical compounds used in various products and applications, high-throughput toxicity screening techniques can help meeting the needs of 21st century risk assessment. Zebrafish (Danio rerio), especially its ear ...
AMER CHEMICAL SOC2020Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities
Patrick Descombes, Sylviane Métairon, Sonia Karaz, Sofia Moco, Tanja Sonntag, Lei Feng
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. H ...
Springer2019Feasibility of neurochemically profiling mouse embryonic brain and its development in utero using 1 H MRS at 14.1 T
Hongxia Lei, Sébastien Robert Victor Herzig
We aimed to evaluate the feasibility of neurochemical profiling of embryonic mouse brain developments in utero and to seek potential in vivo evidence of an energy shift in a mitochondrial pyruvate carrier 1 (MPC1) deficient mouse model. C57BL/6 embryonic m ...
2019Wastewater and green waste biorefinery Degradation of simple sugars using mixed cultures of purple non-sulfur bacteria: an insight into microbial interactions
Purple non-sulfur bacteria (PNSB) are phototrophic organisms that have raised interest for both industrial and domestic wastewater treatment and valorization because of their very high assimilation (~1 g CODX g-1 COD substrate) and valuable compounds produ ...
2019Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size
Suliana Manley, Anna Archetti, Lina Carlini, Charlotte Sophia Floderer, Thaïs Reichler
Protein concentration gradients pattern developing organisms and single cells. In Schizosaccharomyces pombe rod-shaped cells, Pom1 kinase forms gradients with maxima at cell poles. Pom1 controls the timing of mitotic entry by inhibiting Cdr2, which forms s ...
ELIFE SCIENCES PUBLICATIONS LTD2019Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis
Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...
2018Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease
Johan Auwerx, Laia Morato Fornaguera
Pelizaeus-Merzbacher disease (PMD) is a fatal hypomyelinating disorder characterized by early impairment of motor development, nystagmus, choreoathetotic movements, ataxia and progressive spasticity. PMD is caused by variations in the proteolipid protein g ...
2018Identification of the enzymes responsible for diverse phenotypic states of yeast lipid metabolism using comprehensive mechanistic models
Lipids carry an important role in cell structure and function, as well as in the physiopathology of multiple diseases. Maintenance of the lipid profiles should be tightly regulated for preserving membrane permeability, cell integrity and several other func ...
2018