Publications related to Substrate-level phosphorylation

Influence of Uncertainties in pH, pMg, Activity Coefficients, Metabolite Concentrations, and Other Factors on the Analysis of the Thermodynamic Feasibility of Metabolic Pathways

Thermodynamic feasibility analysis (TFA) has been used as a toot capable of providing additional constraints to the mass balance-based methods of analysis of Metabolic networks (e.g., flux balance analysis). Several publications have recently appeared in w ...

2009

Neuroprotective role of lactate after cerebral ischemia

Rolf Gruetter, Pierre Magistretti, Hongxia Lei, Jonathan Thevenet

It is well established that lactate can be used as an energy substrate by the brain by conversion to pyruvate and a subsequent oxidation in the mitochondria. Knowing the need for readily metabolizable substrates directly after ischemia and the protective e ...

2009

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

Pierre Gönczy, Coralie Busso, Isabelle Fluckiger

Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for c ...

2009

The role of sirtuins in the control of metabolic homeostasis

Johan Auwerx, Jiujiu Yu

Recently the function of the sirtuin family, named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2), has received a lot of attention, as their beneficial impact on longevity was linked to their effects on meta ...

2009

THE TWIN-ARGININE TRANSLOCATION PATHWAY IN THE OBLIGATE ANAEROBE DESULFITOBACTERIUM

Christof Holliger, Julien Maillard, Emmanuelle Rohrbach, Aurélie Duret

The genus Desulfitobacterium belong to the low-GC gram-positive phylogenic group and is a versatile obligate anaerobe capable of reducing very diverse terminal electron acceptors such as sulfite, nitrate, fumarate, thiosulfate, and a few polluting chlorina ...

2009

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Hilal Lashuel, Adrian Schmid, Magdalena Zweckstetter

alpha-Synuclein (alpha-syn) phosphorylation at serine 129 is characteristic of Parkinson disease (PD) and related alpha-synulceinopathies. However, whether phosphorylation promotes or inhibits alpha-syn aggregation and neurotoxicity in vivo remains unknown ...

American Society for Biochemistry and Molecular Biology2008

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

Oliver Hantschel

The SH2 domain of cytoplasmic tyrosine kinases can enhance catalytic activity and substrate recognition, but the molecular mechanisms by which this is achieved are poorly understood. We have solved the structure of the prototypic SH2-kinase unit of the hum ...

2008

Spontaneous $ Na ^{ + } $ Transients in Individual Mitochondria of Intact Astrocytes

Michaël Unser, Dimitri Nestor Alice Van De Ville, Jean-Yves Chatton

Mitochondria in intact cells maintain low

Na ^{ + }

levels despite the large electrochemical gradient favoring cation influx into the matrix. In addition, they display individual spontaneous transient depolarizations. We report here that individual mit ...

Wiley-Liss2008

A hardware-software design framework for distributed cellular computing

Pierre-André Mudry, Michel Ganguin, Julien Ruffin

In this article, we describe a novel hardware-software design framework for prototyping cellular architectures in hardware. Based on an extensible platform of about 200 FPGAs, configured as a networked structure of processors, the hardware part of this com ...

2008

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Johan Auwerx

Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mi ...

2006

Substrate-level phosphorylation

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Influence of Uncertainties in pH, pMg, Activity Coefficients, Metabolite Concentrations, and Other Factors on the Analysis of the Thermodynamic Feasibility of Metabolic Pathways

Neuroprotective role of lactate after cerebral ischemia

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

The role of sirtuins in the control of metabolic homeostasis

THE TWIN-ARGININE TRANSLOCATION PATHWAY IN THE OBLIGATE ANAEROBE DESULFITOBACTERIUM

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

Spontaneous $ Na ^{ + } $ Transients in Individual Mitochondria of Intact Astrocytes

A hardware-software design framework for distributed cellular computing

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Influence of Uncertainties in pH, pMg, Activity Coefficients, Metabolite Concentrations, and Other Factors on the Analysis of the Thermodynamic Feasibility of Metabolic Pathways

Neuroprotective role of lactate after cerebral ischemia

The role of sirtuins in the control of metabolic homeostasis

A hardware-software design framework for distributed cellular computing

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

THE TWIN-ARGININE TRANSLOCATION PATHWAY IN THE OBLIGATE ANAEROBE DESULFITOBACTERIUM

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

Spontaneous $ Na ^{ + } $ Transients in Individual Mitochondria of Intact Astrocytes

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation