Concept

Polycystic kidney disease

Related publications (36)

Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisation

Antonia Neels, Marianne Liebi, Tiberiu Totu

Intravenous (IV) iron-carbohydrate complexes are widely used nanoparticles (NPs) to treat iron deficiency anaemia, often associated with medical conditions such as chronic kidney disease, heart failure and various inflammatory conditions. Even though a ple ...

Elsevier2024

New roles of Bicc1 in cilia formation, cell adhesion, and in adult kidneys.

Céline Gagnieux

Bicaudal-C1 (Bicc1), an RNA-Binding protein, is a ciliopathy-associated protein. In development, Bicc1 is necessary for left-right axis specification. Loss of Bicc1 in mice also associates with polycystic kidney development. In human, two hereditary polycy ...

EPFL2023

NAD(+) Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

Vincenzo Sorrentino

Premature aging causes morphological and functional changes in the kidney, leading to chronic kidney disease (CKD). CKD is a global public health issue with far-reaching consequences, including cardio-vascular complications, increased frailty, shortened li ...

MDPI2023

Assessment of Stiffness of Large to Small Arteries in Multistage Renal Disease Model: A Numerical Study

Nikolaos Stergiopoulos, Vasiliki Bikia, Patrick Segers

Arterial stiffness (AS), as assessed via pulse wave velocity (PWV), is a major biomarker for cardiovascular risk assessment in patients with chronic kidney disease (CKD). However, the mechanisms responsible for the changes in PWV in the presence of kidney ...

FRONTIERS MEDIA SA2022

Prospective motion correction in kidney MRI using FID navigators

Tobias Kober

Purpose Abdominal MRI scans may require breath-holding to prevent image quality degradation, which can be challenging for patients, especially children. In this study, we evaluate whether FID navigators can be used to measure and correct for motion prospec ...

WILEY2022

Tissue Engineering with Mechanically Induced Solid‐Fluid Transitions

Mahmut Selman Sakar, Ece Özelçi, Jaemin Kim, Erik Mailand, Nikolaos Bouklas, Matthias Rüegg, Jon Märki, Odysseas Konstantinos Chaliotis

Epithelia are contiguous sheets of cells that stabilize the shape of internal organs and support their structure by covering their surfaces. They acquire diverse morphological forms appropriate for their specific functions during embryonic development, suc ...

2021

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Jacques Fellay, Christian Axel Wandall Thorball

Background In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m(2) per year for >= 3 ...

OXFORD UNIV PRESS INC2021

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

Daniel Constam, Benjamin Marcel Daniel Rothé

Molecular left-right (L-R) asymmetry is established at the node of the mouse embryo as a result of the sensing of a leftward fluid flow by immotile cilia of perinodal crown cells and the consequent degradation of Dand5 mRNA on the left side. We here examin ...

NATURE PORTFOLIO2021

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram

Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...

2021

Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases

Daniel Constam, Benjamin Marcel Daniel Rothé, Céline Gagnieux, Lucía Carolina Leal Esteban

Polycystic kidneys frequently associate with mutations in individual components of cilia, basal bodies or centriolar satellites that perturb complex protein networks. In this review, we focus on the RNA-binding protein Bicaudal-C1 (BICC1) which was found m ...

2020

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