Publications related to Metabolism

Powering the social brain: Mitochondria in social behaviour

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Silvie Rosalie Ruigrok

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

2023

Expanding computational biochemistry towards complex and non-natural compounds

Anastasia Sveshnikova

In the beginning was the metabolism. The biochemical processes that make life possible transformed the soup of chemicals into the life on Earth we know today. Since then, living organisms have evolved, and life on Earth has become more complex. Living orga ...

EPFL2023

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Alexander Hooftman

Background Innate immune cells play a crucial role in responding to microbial infections, but their improper activation can also drive inflammatory disease. For this reason, their activation state is governed by a multitude of factors, including the metabo ...

Basel2023

Breakdown and rejuvenation of aging brain energy metabolism

Henry Markram, Daniel Keller, Jay Coggan, Cyrille Pierre Henri Favreau, Elvis Boci, Polina Shichkova, Stefano Maximiliano Antonel

Cognitive impairments and neurodegeneration in aging are linked to disrupted brain energy metabolism. We address this experimentally challenging problem with a computational molecular model that provides mechanistic insights and therapeutic predictions. Th ...

2023

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

Lijing Xin, Daniel Wenz, Mark Stephan Widmaier, Songi Lim

A new and efficient magnetisation transfer P-31 magnetic resonance fingerprinting (MT-P-31-MRF) approach is introduced to measure the creatine kinase metabolic rate kCK

{k}_{\mathrm{CK}}

between phosphocreatine (PCr) and adenosine triphosphate (ATP) i ...

WILEY2023

NAD(+) Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

Vincenzo Sorrentino

Premature aging causes morphological and functional changes in the kidney, leading to chronic kidney disease (CKD). CKD is a global public health issue with far-reaching consequences, including cardio-vascular complications, increased frailty, shortened li ...

MDPI2023

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

Jeremy Pak Hei Wong

Bacteria often engage in social interactions with neighbouring bacteria. Ecosystems which are subjected to social interactions have been widely studied in well mixed settings such as test tubes, allowing us to identify the cellular components contributingt ...

EPFL2023

Inter- and intra-individual variability in CO2 production and metabolic rate

Dolaana Khovalyg, Mohamad Rida

Carbon dioxide generated by the human body and exhaled (VCO2) is commonly used for ventilation controls, while the metabolic rate (i.e., energy expenditure EE) is an important parameter defining human thermal comfort in buildings. These two parameters are ...

2023

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

Florian Maria Wurm, Guillaume Raussin

Intracellular lipid droplets (LDs) can accumulate in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear ...

Basel2023

An explainability framework for deep learning on chemical reactions exemplified by enzyme-catalysed reaction classification

Daniel Probst

Assigning or proposing a catalysing enzyme given a chemical or biochemical reaction is of great interest to life sciences and chemistry alike. The exploration and design of metabolic pathways and the challenge of finding more sustainable enzyme-catalysed a ...

2023

Metabolism

Graph Chatbot

Chat with Graph Search

Powering the social brain: Mitochondria in social behaviour

Expanding computational biochemistry towards complex and non-natural compounds

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Breakdown and rejuvenation of aging brain energy metabolism

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

NAD(+) Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

Inter- and intra-individual variability in CO2 production and metabolic rate

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

An explainability framework for deep learning on chemical reactions exemplified by enzyme-catalysed reaction classification

Powering the social brain: Mitochondria in social behaviour

Expanding computational biochemistry towards complex and non-natural compounds

Basic Mechanisms of Immunometabolites in Shaping the Immune Response

Fast in vivo assay of creatine kinase activity in the human brain by P-31 magnetic resonance fingerprinting

The Effects of Spatial Organization and Fluid Flow on the Social Interactions in Microbial Communities

NAD(+) Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

An explainability framework for deep learning on chemical reactions exemplified by enzyme-catalysed reaction classification

Breakdown and rejuvenation of aging brain energy metabolism

Inter- and intra-individual variability in CO2 production and metabolic rate

Human PBMCs Form Lipid Droplets in Response to Spike Proteins