Concept
Malaria
Related publications (95)
Potent Virustatic Polymer-Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo
Francesco Stellacci, Matteo Gasbarri
Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanopartides that mimic functional components of ...
AMER CHEMICAL SOC2022NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
Vassily Hatzimanikatis, Jasmin Maria Hafner, Homa Mohammadi Peyhani, Noushin Hadadi, Anush Chiappino-Pepe
The discovery of a drug requires over a decade of intensive research and financial investments – and still has a high risk of failure. To reduce this burden, we developed the NICEdrug.ch resource, which incorporates 250,000 bioactive molecules, and studied ...
2021Automatic detection of potential mosquito breeding sites from aerial images acquired by unmanned aerial vehicles
The World Health Organization (WHO) has stated that effective vector control measures are critical to achieving and sustaining reduction of vector-borne infectious disease incidence. Unmanned aerial vehicles (UAVs), popularly known as drones, can be an imp ...
2021Clinical relevance of low-densityPlasmodium falciparumparasitemia in untreated febrile children: A cohort study
Background Low-density (LD)Plasmodiuminfections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This study i ...
2020Optimization methods and objective functions for analysis of metabolic network models
Computational studies of metabolism aim to systematically analyze the metabolic behaviour of biological systems in different conditions. Genome-scale metabolic network models (GEMs) capture the connection between elements of the network by applying stoichi ...
EPFL2020Epitope Mapping and Fine Specificity of Human T and B Cell Responses for Novel Candidate Blood-Stage Malaria Vaccine P27A
Bruno Emanuel Ferreira De Sousa Correia, Che Yang, Daniel Guignard
P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults in Switzerland and in malaria pre-expo ...
2020Targeting liver stage malaria with metformin
Despite an unprecedented 2 decades of success, the combat against malaria - the mosquito-transmitted disease caused by Plasmodium parasites - is no longer progressing. Efforts toward eradication are threatened by the lack of an effective vaccine and a rise ...
2019Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage
Vassily Hatzimanikatis, Vikash Kumar Pandey, Anush Chiappino-Pepe, Dominique Soldati-Favre
Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed more than 1,300 barcoded P. berghei mutants through the life cycle. We dis ...
CELL PRESS2019Phosphorylation of the VAR2CSA extracellular region is associated with enhanced adhesive properties to the placental receptor CSA
Romain Hamelin, Florence Armand, Marc Moniatte
Plasmodium falciparum is the main cause of disease and death from malaria. P. falciparum virulence resides in the ability of infected erythrocytes (IEs) to sequester in various tissues through the interaction between members of the polymorphic P. falciparu ...
PUBLIC LIBRARY SCIENCE2019Detection of dicistroviruses RNA in blood of febrile Tanzanian children
Mary-Anne Hartley, Thomas Junier
Fever is the leading cause of paediatric outpatient consultations in Sub-Saharan Africa. Although most are suspected to be of viral origin, a putative causative pathogen is not identified in over a quarter of these febrile episodes. Using a de novo assembl ...
TAYLOR & FRANCIS LTD2019