Concept

Intervertebral disc

Related publications (37)

Nanofibrillated cellulose composite hydrogel for the replacement of the nucleus pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Ana Borges de Couraça, Fabien Duc

The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween® 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present stu ...

2011

Heat transfer in Interverterbral Discs (IVDs)

Philippe Abdel Sayed

The Nucleus Pulposus (NP) is an avascular tissue that may be subject to temperature increase. Indeed, since the NP is not perfused by the cardio-vascular system, it implies that heat cannot be convected from it. The sources of heat could be either external ...

2011

Soft-tissue viscoelasticity: extension to anisotropy and finite element implementation

Yannick Alain Frédéric Bastin

Biologic tissues such as the annulus fibrosus of the intervertebral disc present viscoelastic and anisotropic responses to mechanical loading. The objective of this semester project is to propose a method to implement routinely anisotropy-modelling in the ...

2011

Geometry- and load-specific optimization of the collagen network's fibre orientation in the lumbar spine's annulus fibrosus

Andreas Schmocker

In Europe, low back pain (LBP) affects the quality of life of up to 30% of the active population. Although the origin of LBP is not well identified and is probably not unique, epidemiological studies suggest that the severity of the disease is correlated w ...

2010

Composite Hydrogels for the Replacement of the Nucleus Pulposus

Ana Borges de Couraça

The intervertebral disc (IVD), which provides flexibility to the spine and facilitates damping and motion, is composed of two distinct structures: the annulus fibrosus (AF) and the nucleus pulposus (NP). The AF, which is fibrous and elastic, confines the N ...

EPFL2010

Development of a medical instrument to induce and control hydrogel polymerization in-situ

Dominique Pioletti, Pierre-Etienne Bourban, Christophe Moser

Background - Nucleus pulposus degeneration is a very common musculo-skeletal pathology, which is in part responsible for low back pain, a pandemic medical problem. Artificial hydrogels are being investigated by research group around the world for the purpo ...

2010

Curing Kinetics and Mechanical Properties of a Composite Hydrogel for the Replacement of the Nucleus Pulposus

Dominique Pioletti, Pierre-Etienne Bourban, Ana Borges de Couraça

A polymer material system has been developed to propose an injectable, UV and in situ curable hydrogel with properties similar to the native nucleus pulposus of intervertebral disc. Neat hydrogels based on Tween® 20 trimethacrylates (T3) and N-vinyl-2-pyrr ...

Elsevier2010

Soft-tissue viscoelasticity: extension to anisotropy and finite element implementation

Dominique Pioletti, Arne Christian Vogel

Physiological loading result to finite and finite rate of deformations of soft tissues such as ligament, tendons, and the annulus fibrosus of the intervertebral disc. Under these conditions, these soft tissues exhibit viscoelastic effects such as strain-st ...

2009

Does hydrogel-cell construct viscoelasticity affect ECM production?

Line Aschwanden

Low back pain is one of the most prevailing medical concerns and can often be associated with the degeneration of the intervertebral disc. This degeneration results in a loss of biological and mechanical properties, especially a loss of viscoelastic proper ...

2009

Does viscoelasticity of a Hydrogel-cell construct affect ECM production?

Dominique Pioletti, Arne Christian Vogel, Line Aschwanden

Intervertebral disc (IVD) degeneration is one of the prevailing medical concern and actual health cost. Industries and academic institutions research for therapeutic solutions going from drugs to complete and partial arthroplasty devices as well as enginee ...

2009

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