Concept
Leptin
Related publications (60)
Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass
Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman, Yoo Hoon Kim
Adipose tissues serve as an energy reservoir and endocrine organ, yet the mechanisms that coordinate these functions remain elusive. Here, we show that the transcriptional coregulators, YAP and TAZ, uncouple fat mass from leptin levels and regulate adipocy ...
Nature Portfolio2024Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion
Amino acid availability is monitored by animals to adapt to their nutritional environment. Beyond gustatory receptors and systemic amino acid sensors, enteroendocrine cells (EECs) are believed to directly percept dietary amino acids and secrete regulatory ...
Nature Portfolio2024Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...
Elsevier2022Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans
Richardus Houtkooper, Wen Gao, Yuan Liu
Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...
NATURE PORTFOLIO2022