Concept
Lactation
Related publications (25)
Estrogen receptor signaling in the human breast epithelium
Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...
EPFL2022Premature Vertebral Mineralization in hmx1-Mutant Zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development, and mutations in HMX1 are linked to an ocular defect termed oculoauricular syndrome of Schorderet-Munier-Franceschetti (OAS) (MIM #612109). Recently, additional altered oro ...
2022Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment
Compared to estrogen receptor-negative (ER-) breast cancer (BC), ER+ BC often manifests with a latent disease that recurs decades after initial diagnosis. The mechanisms governing dormancy and distant recurrence of ER+ tumors remain elusive due to the lack ...
EPFL2021Big dairy data to unravel effects of environmental, physiological and morphological factors on milk production of mountain-pastured Braunvieh cows
The transhumance system, which consists in moving animals to high mountain pastures during summer, plays a considerable role in preserving both local biodiversity and traditions, as well as protecting against natural hazard. In cows, particularly, milk pro ...
ROYAL SOC2020Intraductal patient-derived xenografts of estrogen receptor α-positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions
Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Laura Battista, Maryse Fiche, Valentina Scabia, Patrik Aouad, Valérian Charles Robert Dormoy
Estrogen receptor α-positive (ER-positive) or 'luminal' breast cancers were notoriously difficult to establish as patient-derived xenografts (PDXs). We and others recently demonstrated that the microenvironment is critical for ER-positive tumor cells; when ...
2018Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT
Denis Duboule, Jozsef Zakany, Fabrice Daniel Darbellay, Anamaria Necsulea
During embryonic development, Hox genes participate in the building of a functional digestive system in metazoans, and genetic conditions involving these genes lead to important, sometimes lethal,growth retardation. Recently, this phenotype was obtained af ...
Proceedings of the National Academy of Sciences2017Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury
Lactoferrin (Lf), component of maternal milk, has antioxidant, anti-inflammatory and antimicrobial properties. Neuroprotective effects of Lf on the immature brain have been recently shown in rodent models of intrauterine growth restriction and cerebral hyp ...
Wiley-Blackwell2016Fostering of advanced mutualism with gut microbiota by Immunoglobulin A
Immunoglobulin A (IgA), the most abundantly secreted antibody isotype in mammals, not only provides direct immune protection to neonates via maternal milk but also helps program the infant immune system by regulating the microbiota. IgA continues to mainta ...
Wiley-Blackwell2016Mechanisms underlying cell-fate determination in the mammary gland development
Notch signaling pathway is an important developmental pathway and has been implicated in both mammary gland development and tumorigenesis. Several studies investigating Notch signaling in mouse mammary gland implied that Notch signaling is an important fac ...
EPFL2015Inflammatory lymphangiogenesis in postpartum breast tissue remodeling
Like many cancers, mammary carcinomas use lymphatic vessels to disseminate, and numerous clinical and experimental studies have documented a strong correlation between peritumoral lymphangiogenesis and tumor dissemination. At the same time, many other fact ...
American Society for Clinical Investigation2014